2022
The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results
Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A, Imai T, Qin T, Ayata C, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A, Siddiqui S, Sheth K, Matouk C, Cruz C, Zhou J, Dawson V, Dawson T, Liang J, van Zijl P, Zeiler S, Taylor Kimberly W, Erdogan T, Yu L, Mandeville J, Whittier J. The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke 2022, 53: 1802-1812. PMID: 35354299, PMCID: PMC9038686, DOI: 10.1161/strokeaha.121.038047.Peer-Reviewed Original ResearchConceptsPreclinical assessmentStroke treatmentCandidate treatmentMiddle cerebral artery occlusion (MCAO) surgeryClinical stroke trialsSuccessful stroke treatmentInclusion/exclusion criteriaStroke clinical trialsClinical trial designYoung male animalsComorbid diseasesOcclusion surgeryCerebral ischemiaNeurological disabilityComorbid conditionsStroke trialsProtocol adherenceBlinded assessmentSuch therapyClinical trialsClinical studiesExclusion criteriaTrial designAged animalsOutcome assessment
2021
Top Priorities for Cerebroprotective Studies—A Paradigm Shift
Lyden P, Buchan A, Boltze J, Fisher M, Ansari S, Broderick J, Campbell B, Chaisinanunkul N, Chen C, Grotta J, Haddad W, Hareedy R, Hill M, Houser G, Jadhav A, Khatri P, Kimberly W, Koenig J, Korinek W, Landen J, Lansberg M, Latour L, Liebeskind D, Liston T, Lynch J, McGonigle J, Mistry E, Mocco J, Pryor K, Saver J, Savitz S, Sheth K, Solberg Y, Vagal A, Venkatasubramanian C, Ziogas N. Top Priorities for Cerebroprotective Studies—A Paradigm Shift. Stroke 2021, 52: 3063-3071. PMID: 34289707, PMCID: PMC8384700, DOI: 10.1161/strokeaha.121.034947.Peer-Reviewed Original ResearchConceptsComprehensive preclinical assessmentPreclinical assessmentNeurovascular unitMajor public health concernSalvageable brain tissueStroke symptom onsetIschemic stroke treatmentBlood-brain barrierConsensus-based recommendationsPharmacokinetics/pharmacodynamicsClinical trial designPaucity of evidencePublic health concernDifferent brain regionsMechanism of actionCerebroprotective agentTerm neuroprotectionIschemic strokeSymptom onsetStroke treatmentClinical outcomesComorbid conditionsCore injuryClinical trialsStroke model