Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations
Liu Q, Jin WN, Liu Y, Shi K, Sun H, Zhang F, Zhang C, Gonzales RJ, Sheth KN, La Cava A, Shi FD. Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations. Immunity 2017, 46: 474-487. PMID: 28314594, DOI: 10.1016/j.immuni.2017.02.015.Peer-Reviewed Original ResearchConceptsPost-stroke infectionsBrain ischemiaMiddle cerebral artery occlusionCell-mediated immune defenseAdrenal axis leadsNK cell numbersCerebral artery occlusionNK cell responsesNK cell functionNatural killer cellsExpression of SOCS3Infectious complicationsArtery occlusionImmune alterationsIschemic strokeSplenic atrophyKiller cellsImmune functionCell responsesGenetic ablationIschemiaImmune defenseBrainCell functionInnervation