Tissue plasminogen activator mobilizes neutrophils and T cells that exacerbate hemorrhagic transformation in stroke
Shi K, Liu Q, Jia D, Yang X, Zou M, Shi S, Dong J, Sheth K, Wang X, Shi F. Tissue plasminogen activator mobilizes neutrophils and T cells that exacerbate hemorrhagic transformation in stroke. The Journal Of Immunology 2020, 204: 64.21-64.21. DOI: 10.4049/jimmunol.204.supp.64.21.Peer-Reviewed Original ResearchTissue plasminogen activatorT cellsEmbolic strokeHemorrhagic transformationNeurovascular unitThrombolytic therapyBrain hemorrhageEffects of tPAPlasminogen activatorFocal embolic strokeIschemic stroke patientsMyeloid cell recruitmentMigration of neutrophilsTPA thrombolysisHemorrhagic complicationsIschemic strokeLymphocyte egressEndothelial injuryNeurological functionStroke patientsImmune modulationRat modelCell recruitmentImmune invasionNeutrophils