2024
Fever Prevention in Patients With Acute Vascular Brain Injury
Greer D, Helbok R, Badjatia N, Ko S, Guanci M, Sheth K, Diringer M, Mehta Y, Cava L, Hinduja A, Lele A, Sarwal A, Kulik T, Keller E, Smith G, Dennesen P, Dimitriadis K, Schonenberger S, Gunther A, Meisel A, Wolf S, Kollmar R, Barlinn K, Jeon S, Han M, Hong J, Lee R, Falcone G, Dashti S, Busl K, Ermak D, Berkeley J, Amory C, Swor R, DeGeorgia M, Green-LaRoche D, Thompson B, Hatton K, Sung G, Mehta C, Zurasky J, Da Silva I, James M, Aysenne A, Cervantes A, Devlin T, Chang I, Morris N, Venkatasubramanian C, Mushlschlegel S, Zachariah J, Chaudry F, Claassen J, Dangayach N, Choi H, Sadaka F, Miller C. Fever Prevention in Patients With Acute Vascular Brain Injury. JAMA 2024, 332: 1525-1534. PMID: 39320879, PMCID: PMC11425189, DOI: 10.1001/jama.2024.14745.Peer-Reviewed Original ResearchVascular brain injuryStandard care groupCare groupMajor adverse eventsPrimary outcomeStandard care patientsBlinded outcome assessmentIntensive care unit dischargeFunctional outcomesAdverse eventsBrain injuryFever preventionFever burdenPrincipal secondary end pointBetween-group differencesOpen-label randomized clinical trialPrevention groupFunctional recoveryPrincipal secondary outcomeCare patientsAssociated with worse outcomesMain OutcomesImpact functional outcomesSecondary end pointsTemperature management deviceImpaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies
Sharma R, de Havenon A, Rivier C, Payabvash S, Forman R, Krumholz H, Falcone G, Sheth K, Kernan W. Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies. BMJ Neurology Open 2024, 6: e000501. PMID: 38288313, PMCID: PMC10823923, DOI: 10.1136/bmjno-2023-000501.Peer-Reviewed Original ResearchVascular brain injurySlow walkingAtherosclerosis RiskMobility impairmentsAssociated with mobility impairmentImpaired mobilityUK Biobank (UKBStroke-free cohortMarkers of vascular brain injuryAdjusted multivariate logistic regression analysisGait dataMultivariate logistic regression analysisCommunity-dwellingLogistic regression analysisBrain injuryARICUKBInclusion criteriaStudy cohortWalkingClinical strokeRegression analysisImpaired outcomeMRI markersStudy backgroundPeri-hematomal edema shape features related to 3-month outcome in acute supratentorial intracerebral hemorrhage
Dierksen F, Tran A, Zeevi T, Maier I, Qureshi A, Sanelli P, Werring D, Malhotra A, Falcone G, Sheth K, Payabvash S. Peri-hematomal edema shape features related to 3-month outcome in acute supratentorial intracerebral hemorrhage. European Stroke Journal 2024, 9: 383-390. PMID: 38179883, PMCID: PMC11318427, DOI: 10.1177/23969873231223814.Peer-Reviewed Original ResearchNIH Stroke ScaleGlasgow Coma ScaleAssociation of baselineIntracerebral hemorrhagePerihematomal edemaHematoma volumeAcute supratentorial intracerebral hemorrhageNon-traumatic intracerebral hemorrhageSecondary brain injuryAcute ICH patientsIndependent prognostic factorSupratentorial intracerebral hemorrhageAdmission NIH Stroke ScalePotential treatment targetRankin scoreStroke ScaleIndependent predictorsPatient agePrognostic factorsComa ScaleMultivariable analysisICH patientsPrognostic valueBrain injuryFavorable outcome
2023
Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study
Abou Karam G, Tharmaseelan H, Aboian M, Malhotra A, Gilmore E, Falcone G, de Havenon A, Sheth K, Payabvash S. Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107375. PMID: 37738914, PMCID: PMC10591892, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107375.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSecondary brain injuryIntracerebral hemorrhagePerihematomal edemaSubacute intracerebral hemorrhageIntravoxel incoherent motion imagingAdmission NIHSSBrain injuryMedian baseline National InstitutesPilot studyBaseline National InstitutesHealth Stroke ScalePerfusion fractionSupratentorial intracerebral hemorrhageIVIM metricsIncoherent motion imagingStroke ScaleNeuroprotective therapiesParenchymal injuryRankin ScaleRisk patientsConsecutive patientsUnivariable analysisPoor outcomeICH volumeLow‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury
Sujijantarat N, Koo A, Jambor I, Malhotra A, Mazurek M, Parasuram N, Yadlapalli V, Chavva I, Lalwani D, Zabinska J, Roy J, Antonios J, Elsamadicy A, Renedo D, Hebert R, Schindler J, Gilmore E, Sansing L, de Havenon A, Olexa M, Schiff S, Iglesias J, Rosen M, Kimberly W, Petersen N, Sheth K, Matouk C. Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.123.000921.Peer-Reviewed Original ResearchMechanical thrombectomyInterventional radiology suiteMagnetic resonance imagingRadiology suiteConventional MRIResonance imagingCerebral Infarction scoreOngoing brain injuryLarge vessel occlusionInfarct burdenRevascularization timeInfarct volumeClinical characteristicsInfarct progressionAdverse eventsIschemic changesMethods PatientsMedian timeBedside evaluationBrain injuryTimely imagingResults TwentyPatientsSubsequent imagingProcedural detailsSleep Duration is Associated with Clinically Silent Brain Injury in Middle-Aged Persons without Stroke (P1-13.004)
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Torres-Lopez V, Payabvash S, Sheth K, Gill T, Falcone G. Sleep Duration is Associated with Clinically Silent Brain Injury in Middle-Aged Persons without Stroke (P1-13.004). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202523.Peer-Reviewed Original Research
2022
Nanoparticle-based drug delivery for the treatment of traumatic brain injury
Mohammed F, Omay S, Sheth K, Zhou J. Nanoparticle-based drug delivery for the treatment of traumatic brain injury. Expert Opinion On Drug Delivery 2022, 20: 55-73. PMID: 36420918, PMCID: PMC9983310, DOI: 10.1080/17425247.2023.2152001.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injurySecondary outcomesClinical trialsPathophysiology of TBIPhase III clinical trialsPhase II clinical trialClinical management strategiesSite of injuryOff-target toxicityPharmacological treatmentBrain penetrationLow off-target toxicityExperimental animalsInjuryChronic timescalesDosage thresholdDrug deliveryTrialsDrug targetingOutcomesTreatmentDeliveryPathophysiologyCerebral Autoregulatory Function Before, During, and After Therapeutic Interventions Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study (S21.001)
Prasad A, Kobsa J, Soto A, Bartolome D, Begunova L, Kim J, Gilmore E, Sheth K, Matouk C, De Havenon A, Diaz-Arrastia R, Petersen N. Cerebral Autoregulatory Function Before, During, and After Therapeutic Interventions Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study (S21.001). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.557.Peer-Reviewed Original Research
2021
Low-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349)
Mazurek M, Yuen M, Cahn B, Rosen M, Gobeske K, Gilmore E, Hwang D, Kaddouh F, Kim J, Falcone G, Petersen N, Siner J, Spudich S, Sze G, Kimberly W, Sheth K. Low-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.1349.Peer-Reviewed Original Research
2018
Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
James S, Theadom A, Ellenbogen R, Bannick M, Montjoy-Venning W, Lucchesi L, Abbasi N, Abdulkader R, Abraha H, Adsuar J, Afarideh M, Agrawal S, Ahmadi A, Ahmed M, Aichour A, Aichour I, Aichour M, Akinyemi R, Akseer N, Alahdab F, Alebel A, Alghnam S, Ali B, Alsharif U, Altirkawi K, Andrei C, Anjomshoa M, Ansari H, Ansha M, Antonio C, Appiah S, Ariani F, Asefa N, Asgedom S, Atique S, Awasthi A, Ayala Quintanilla B, Ayuk T, Azzopardi P, Badali H, Badawi A, Balalla S, Banstola A, Barker-Collo S, Bärnighausen T, Bedi N, Behzadifar M, Behzadifar M, Bekele B, Belachew A, Belay Y, Bennett D, Bensenor I, Berhane A, Beuran M, Bhalla A, Bhaumik S, Bhutta Z, Biadgo B, Biffino M, Bijani A, Bililign N, Birungi C, Boufous S, Brazinova A, Brown A, Car M, Cárdenas R, Carrero J, Carvalho F, Castañeda-Orjuela C, Catalá-López F, Chaiah Y, Champs A, Chang J, Choi J, Christopher D, Cooper C, Crowe C, Dandona L, Dandona R, Daryani A, Davitoiu D, Degefa M, Demoz G, Deribe K, Djalalinia S, Do H, Doku D, Drake T, Dubey M, Dubljanin E, El-Khatib Z, Ofori-Asenso R, Eskandarieh S, Esteghamati A, Esteghamati S, Faro A, Farzadfar F, Farzaei M, Fereshtehnejad S, Fernandes E, Feyissa G, Filip I, Fischer F, Fukumoto T, Ganji M, Gankpe F, Gebre A, Gebrehiwot T, Gezae K, Gopalkrishna G, Goulart A, Haagsma J, Haj-Mirzaian A, Haj-Mirzaian A, Hamadeh R, Hamidi S, Haro J, Hassankhani H, Hassen H, Havmoeller R, Hawley C, Hay S, Hegazy M, Hendrie D, Henok A, Hibstu D, Hoffman H, Hole M, Homaie Rad E, Hosseini S, Hostiuc S, Hu G, Hussen M, Ilesanmi O, Irvani S, Jakovljevic M, Jayaraman S, Jha R, Jonas J, Jones K, Jorjoran Shushtari Z, Jozwiak J, Jürisson M, Kabir A, Kahsay A, Kahssay M, Kalani R, Karch A, Kasaeian A, Kassa G, Kassa T, Kassa Z, Kengne A, Khader Y, Khafaie M, Khalid N, Khalil I, Khan E, Khan M, Khang Y, Khazaie H, Khoja A, Khubchandani J, Kiadaliri A, Kim D, Kim Y, Kisa A, Koyanagi A, Krohn K, Kuate Defo B, Kucuk Bicer B, Kumar G, Kumar M, Lalloo R, Lami F, Lansingh V, Laryea D, Latifi A, Leshargie C, Levi M, Li S, Liben M, Lotufo P, Lunevicius R, Mahotra N, Majdan M, Majeed A, Malekzadeh R, Manda A, Mansournia M, Massenburg B, Mate K, Mehndiratta M, Mehta V, Meles H, Melese A, Memiah P, Mendoza W, Mengistu G, Meretoja A, Meretoja T, Mestrovic T, Miazgowski T, Miller T, Mini G, Mirica A, Mirrakhimov E, Moazen B, Mohammadi M, Mohammed S, Mokdad A, Molokhia M, Monasta L, Mondello S, Moosazadeh M, Moradi G, Moradi M, Moradi-Lakeh M, Moradinazar M, Morrison S, Moschos M, Mousavi S, Murthy S, Musa K, Mustafa G, Naghavi M, Naik G, Najafi F, Nangia V, Nascimento B, Negoi I, Nguyen T, Nichols E, Ningrum D, Nirayo Y, Nyasulu P, Ogbo F, Oh I, Okoro A, Olagunju A, Olagunju T, Olivares P, Otstavnov S, Owolabi M, P A M, Pakhale S, Pandey A, Pesudovs K, Pinilla-Monsalve G, Polinder S, Poustchi H, Prakash S, Qorbani M, Radfar A, Rafay A, Rafiei A, Rahimi-Movaghar A, Rahimi-Movaghar V, Rahman M, Rahman M, Rai R, Rajati F, Ram U, Rawaf D, Rawaf S, Reiner R, Reis C, Renzaho A, Resnikoff S, Rezaei S, Rezaeian S, Roever L, Ronfani L, Roshandel G, Roy N, Ruhago G, Saddik B, Safari H, Safiri S, Sahraian M, Salamati P, Saldanha R, Samy A, Sanabria J, Santos J, Santric Milicevic M, Sartorius B, Satpathy M, Savuon K, Schneider I, Schwebel D, Sepanlou S, Shabaninejad H, Shaikh M, Shams-Beyranvand M, Sharif M, Sharif-Alhoseini M, Shariful Islam S, She J, Sheikh A, Shen J, Sheth K, Shibuya K, Shiferaw M, Shigematsu M, Shiri R, Shiue I, Shoman H, Siabani S, Siddiqi T, Silva J, Silveira D, Sinha D, Smith M, Soares Filho A, Sobhani S, Soofi M, Soriano J, Soyiri I, Stein D, Stokes M, Sufiyan M, Sunguya B, Sunshine J, Sykes B, Szoeke C, Tabarés-Seisdedos R, Te Ao B, Tehrani-Banihashemi A, Tekle M, Temsah M, Temsah O, Topor-Madry R, Tortajada-Girbés M, Tran B, Tran K, Tudor Car L, Ukwaja K, Ullah I, Usman M, Uthman O, Valdez P, Vasankari T, Venketasubramanian N, Violante F, Wagnew F, Waheed Y, Wang Y, Weldegwergs K, Werdecker A, Wijeratne T, Winkler A, Wyper G, Yano Y, Yaseri M, Yasin Y, Ye P, Yimer E, Yip P, Yisma E, Yonemoto N, Yoon S, Yost M, Younis M, Yousefifard M, Yu C, Zaidi Z, Zaman S, Zamani M, Zenebe Z, Zodpey S, Feigin V, Vos T, Murray C. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology 2018, 18: 56-87. PMID: 30497965, PMCID: PMC6291456, DOI: 10.1016/s1474-4422(18)30415-0.Peer-Reviewed Original ResearchConceptsSpinal cord injuryTraumatic brain injuryCause of injuryAge-standardised incidence ratesMedical careNew casesCord injuryNational burdenBrain injuryIncidence rateGlobal burdenProportion of TBIIncidence of TBIBayesian meta-regression toolGlobal injury burdenAge-standardised prevalenceDisease Study 2016Long-term disabilityCause-specific mortality ratesAge-standardised ratesStandardised mortality ratiosNature of injurySocio-demographic IndexGlobal health priorityRoad injuries
2016
Predicting survival after acute civilian penetrating brain injuries
Muehlschlegel S, Ayturk D, Ahlawat A, Izzy S, Scalea TM, Stein DM, Emhoff T, Sheth KN. Predicting survival after acute civilian penetrating brain injuries. Neurology 2016, 87: 2244-2253. PMID: 27784772, PMCID: PMC5123553, DOI: 10.1212/wnl.0000000000003355.Peer-Reviewed Original ResearchConceptsRadiologic factorsBrain injuryMotor Glasgow Coma ScaleLower Injury Severity ScoreLevel 1 trauma centerLower international normalized ratioUS level 1 trauma centersSurvival prediction scoreInjury Severity ScoreGlasgow Coma ScaleInternational normalized ratioMultivariable logistic regressionTraumatic brain injurySelf-inflicted injurySurvival prediction toolHospital dischargeComa ScaleLocal traumaPenetrating injuryTrauma centerMean ageNormalized ratioFemale sexSeverity scorePupillary reactivity
2012
Intracranial Pressure Dose and Outcome in Traumatic Brain Injury
Sheth KN, Stein DM, Aarabi B, Hu P, Kufera JA, Scalea TM, Hanley DF. Intracranial Pressure Dose and Outcome in Traumatic Brain Injury. Neurocritical Care 2012, 18: 26-32. PMID: 23055087, DOI: 10.1007/s12028-012-9780-3.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryTraumatic brain injuryElevated intracranial pressureBrain injuryIntracranial pressureFunctional outcomeExtended Glasgow Outcome ScaleCenter observational studyCornerstone of managementGlasgow Outcome ScalePoor functional outcomeIntracranial pressure measurementClinical outcomesOutcome ScaleUniversity HospitalObservational studyProspective patientsCandidate biomarkersInjuryTime doseConclusionsThese resultsOutcomesPatientsMortalityDoseTraditional systolic blood pressure targets underestimate hypotension-induced secondary brain injury
Brenner M, Stein D, Hu P, Aarabi B, Sheth K, Scalea T. Traditional systolic blood pressure targets underestimate hypotension-induced secondary brain injury. Journal Of Trauma And Acute Care Surgery 2012, 72: 1456-1457. DOI: 10.1097/01.ta.0000414833.80358.72.Peer-Reviewed Original Research