Glyburide is Associated with Attenuated Vasogenic Edema in Stroke Patients
Kimberly WT, Battey TW, Pham L, Wu O, Yoo AJ, Furie KL, Singhal AB, Elm JJ, Stern BJ, Sheth KN. Glyburide is Associated with Attenuated Vasogenic Edema in Stroke Patients. Neurocritical Care 2013, 20: 193-201. PMID: 24072459, PMCID: PMC5198519, DOI: 10.1007/s12028-013-9917-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkersBrain EdemaBrain IschemiaCase-Control StudiesClinical Trials as TopicCohort StudiesDouble-Blind MethodFemaleGlyburideHumansHypoglycemic AgentsMagnetic Resonance ImagingMaleMatrix Metalloproteinase 9Middle AgedPilot ProjectsRandom AllocationRetrospective StudiesStrokeTreatment OutcomeConceptsVasogenic edemaIschemic strokeStroke patientsMagnetic resonance imagesMatrix metalloproteinase-9 plasma levelsSerial brain magnetic resonance imagesTransient receptor potential cation channelM member 4Secondary neurological deteriorationPlacebo-controlled trialMMP-9 levelsLarge hemispheric strokeBrain magnetic resonance imagesPreclinical rodent modelsSulfonylurea receptor 1Case-control designBrain swellingCerebral edemaNeurological deteriorationHuman strokeSerious complicationsGlyburide treatmentHemispheric strokeBlood biomarkersBlood markers