The Microenvironment of Germ Cell Tumors Harbors a Prominent Antigen-Driven Humoral Response
Willis SN, Mallozzi SS, Rodig SJ, Cronk KM, McArdel SL, Caron T, Pinkus GS, Lovato L, Shampain KL, Anderson DE, Anderson RC, Bruce JN, O’Connor KC. The Microenvironment of Germ Cell Tumors Harbors a Prominent Antigen-Driven Humoral Response. The Journal Of Immunology 2009, 182: 3310-3317. PMID: 19234230, DOI: 10.4049/jimmunol.0803424.Peer-Reviewed Original ResearchConceptsImmune cell infiltratesGerm cell tumorsHumoral immune responseCell infiltrateB cellsCell tumorsImmune responseGerm cell tumor biologyGerm cell tumor subtypesTumor-associated B cellsTumor-infiltrating B cellsTumor microenvironmentSpecific humoral immune responseRole B cellsB cell clonal expansionB-cell infiltratesB cell responsesCell clonal expansionB cell maturationSignificant somatic mutationsLymphoid folliclesHumoral responsePeripheral bloodTumor subtypesCardinal features