2007
A Local Antigen-Driven Humoral Response Is Present in the Inflammatory Myopathies
Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA, O’Connor K. A Local Antigen-Driven Humoral Response Is Present in the Inflammatory Myopathies. The Journal Of Immunology 2007, 178: 547-556. PMID: 17182595, DOI: 10.4049/jimmunol.178.1.547.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmino Acid SequenceAntibody FormationAutoantigensB-Lymphocyte SubsetsFemaleGenes, Immunoglobulin Heavy ChainHumansImmunoglobulin Switch RegionImmunoglobulin Variable RegionMaleMicrodissectionMiddle AgedMolecular Sequence DataMutationMyocardiumMyositisReceptors, Antigen, B-CellSyndecan-1Transcription, GeneticConceptsInclusion body myositisLaser capture microdissectionBody myositisCapture microdissectionInflammatory myopathiesMuscle tissueInsertions/deletionsT cell-mediated diseaseGene sequencesCell-mediated diseaseGene transcriptsInflamed muscle tissueAg-specific responsesAg receptorB cell maturationPlasma cell populationPutative autoimmune disordersControl muscle tissueSignificant somatic mutationsIndividual cellsVariable region gene sequencesOligoclonal expansionInflammatory infiltrateSomatic mutationsMuscle weakness
2005
Plasma cells in muscle in inclusion body myositis and polymyositis
Greenberg S, Bradshaw E, Pinkus J, Pinkus G, Burleson T, Due B, Bregoli L, O’Connor K, Amato A. Plasma cells in muscle in inclusion body myositis and polymyositis. Neurology 2005, 65: 1782-1787. PMID: 16344523, DOI: 10.1212/01.wnl.0000187124.92826.20.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, SurfaceAutoantigensBiomarkersBiopsyB-LymphocytesCell DifferentiationCell LineageHumansImmunoglobulinsImmunohistochemistryLymphocyte ActivationMembrane GlycoproteinsMuscle, SkeletalMyositis, Inclusion BodyPlasma CellsPolymyositisProteoglycansRNA, MessengerSyndecan-1SyndecansT-LymphocytesConceptsInclusion body myositisBody myositisB cellsImmunoglobulin gene transcriptsPlasma cellsImmunohistochemical studyCell-mediated immune mechanismsMore T cellsT cell populationsMuscles of patientsMuscle biopsy specimensPrevious immunohistochemical studiesB cell activationDifferentiated B cellsB-cell lineageCell surface markersImmunoglobulin gene rearrangementsUntreated patientsHumoral mechanismsBiopsy specimensImmune mechanismsLaser capture microdissectionT cellsPolymyositisMyositis