Methylation profiling of locally advanced rectal cancer (LARC): Exploration of potential predictive markers for neoadjuvant chemoradiation (NACR).
Guo S, Melamed J, Eze O, Bowman C, Ahmed S, Moore H, Loomis C, Heguy A, Brody R, Morrison D, Serrano J, Du K, Wu J, Ryan T, Cohen D, Gu P, Goldberg J, Snuderl M, Leichman L, Leichman C. Methylation profiling of locally advanced rectal cancer (LARC): Exploration of potential predictive markers for neoadjuvant chemoradiation (NACR). Journal Of Clinical Oncology 2016, 34: 614-614. DOI: 10.1200/jco.2016.34.4_suppl.614.Peer-Reviewed Original ResearchTotal mesorectal excisionNeoadjuvant chemoradiationLaser capture microdissectionRectal cancerInvasive carcinomaNormal epitheliumNew York University HospitalFuture prospective trialsComplete pathologic responseAdvanced rectal cancerPotential predictive markerOptimal clinical outcomesPathologic responseProspective trialMesorectal excisionClinical outcomesColorectal cancerInflammatory cellsPathologic outcomesPredictive biomarkersPredictive markerUniversity HospitalPathologic resultsH3K27me3 immunohistochemistryClinical cohort