Genome-wide DNA methylation profiles in progression to in situand invasive carcinoma of the breast with impact on gene transcription and prognosis
Fleischer T, Frigessi A, Johnson K, Edvardsen H, Touleimat N, Klajic J, Riis M, Haakensen V, Wärnberg F, Naume B, Helland Å, Børresen-Dale A, Tost J, Christensen B, Kristensen V. Genome-wide DNA methylation profiles in progression to in situand invasive carcinoma of the breast with impact on gene transcription and prognosis. Genome Biology 2014, 15: 435. PMID: 25146004, PMCID: PMC4165906, DOI: 10.1186/s13059-014-0435-x.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCpG IslandsDisease ProgressionDNA MethylationEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHumansPrognosisSurvival AnalysisTranscription, GeneticConceptsGenome-wide DNA methylation profilesDNA methylation profilesMethylation profilesInvasive breast carcinomaProgression of cancerBreast carcinomaDNA methylation alterationsPrognostic signatureDNA methylation-based markersCancer Genome AtlasDNA methylationGene transcriptionMethylation changesMethylation-based markersEpigenetic changesMethylation alterationsSurvival of patientsGene expressionBreast cancer patientsMethylation levelsNormal breast tissueBreast cancer samplesClinical decision makingGenesGenome Atlas