DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer
Johnson K, Koestler D, Fleischer T, Chen P, Jenson E, Marotti J, Onega T, Kristensen V, Christensen B. DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer. Clinical Epigenetics 2015, 7: 75. PMID: 26213588, PMCID: PMC4514996, DOI: 10.1186/s13148-015-0094-0.Peer-Reviewed Original ResearchInvasive breast cancerAdjacent normal tissuesInvasive diseaseBreast cancerDuctal carcinomaEstrogen receptor-positive DCISEarly-stage breast cancerAccurate risk stratificationAge-matched subjectsStage breast cancerInvasive ductal carcinomaCancer Genome Atlas (TCGA) databasePre-invasive lesionsAppropriate treatment decisionsIllumina HumanMethylation450K arrayBackgroundDuctal carcinomaPositive DCISInvasive recurrenceDCIS progressionDCIS casesProgression of cancerRisk stratificationDisease progressionTreatment decisionsClinical challenge