The theoretical basis of transcriptional therapy of cancer: can it be put into practice?
Melnick AM, Adelson K, Licht JD. The theoretical basis of transcriptional therapy of cancer: can it be put into practice? Journal Of Clinical Oncology 2005, 23: 3957-70. PMID: 15867201, DOI: 10.1200/jco.2005.14.498.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA MethylationForecastingGene SilencingHumansNeoplasmsPromoter Regions, GeneticTranscription, GeneticConceptsDNA repair-related genesRepair-related genesCombination of genesChromatin remodelingTranscriptional repressionGene regulationTranscriptional therapyGenetic reprogrammingTranscription factorsAberrant genesTumor suppressorNeoplastic phenotypeGenesRecent discoveryMolecular pathogenesisCritical roleMajor mechanismFrequent eventMalignant transformationCellsReprogrammingRepressionSuppressorHypermethylationMechanism