2017
Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53
Kenny TC, Schmidt H, Adelson K, Hoshida Y, Koh AP, Shah N, Mandeli J, Ting J, Germain D. Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53. Clinical Cancer Research 2017, 23: 5446-5459. PMID: 28630214, PMCID: PMC5600839, DOI: 10.1158/1078-0432.ccr-17-0342.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCell Line, TumorCell MovementCell ProliferationCollagenDiagnostic ImagingDisease Models, AnimalDisease SusceptibilityExtracellular FluidFemaleGene Expression ProfilingHeterograftsHumansImmunohistochemistryMiceModels, BiologicalNeoplasm GradingNeoplasm InvasivenessRetrospective StudiesTumor Suppressor Protein p53ConceptsMammary glandBilateral mastectomy patientsInvasion scoreHigh-grade primary tumorsInterstitial fluidNormal mammary glandClin Cancer ResSporadic breast cancerBreast cancer cellsVisceral metastasesSpontaneous tumor formationClinical courseDuctal hyperplasiaResidual diseaseMastectomy patientsPrimary tumorDisease progressionRadiologic examinationBreast cancerLocal invasionMouse modelCollagen depositionMyofibroblast differentiationCancer ResExtracellular matrix
2016
Lactation opposes pappalysin‐1‐driven pregnancy‐associated breast cancer
Takabatake Y, Oxvig C, Nagi C, Adelson K, Jaffer S, Schmidt H, Keely PJ, Eliceiri KW, Mandeli J, Germain D. Lactation opposes pappalysin‐1‐driven pregnancy‐associated breast cancer. EMBO Molecular Medicine 2016, 8: 388-406. PMID: 26951623, PMCID: PMC4818749, DOI: 10.15252/emmm.201606273.Peer-Reviewed Original ResearchConceptsPregnancy-associated breast cancerBreast cancerMammary tumorsDeposition of collagenIGFBP-4Mouse mammary glandIGFBP-5Protective effectEffect of lactationPappalysin-1Expression of inhibitorTransgenic micePAPPPregnancyCancerTransient increaseTumor-associated collagen signaturesMammary glandCollagen signaturesTumorsTransgenic expressionLactationProliferative signalingOncogeneCollagen