Lactation opposes pappalysin‐1‐driven pregnancy‐associated breast cancer
Takabatake Y, Oxvig C, Nagi C, Adelson K, Jaffer S, Schmidt H, Keely PJ, Eliceiri KW, Mandeli J, Germain D. Lactation opposes pappalysin‐1‐driven pregnancy‐associated breast cancer. EMBO Molecular Medicine 2016, 8: 388-406. PMID: 26951623, PMCID: PMC4818749, DOI: 10.15252/emmm.201606273.Peer-Reviewed Original ResearchConceptsPregnancy-associated breast cancerBreast cancerMammary tumorsDeposition of collagenIGFBP-4Mouse mammary glandIGFBP-5Protective effectEffect of lactationPappalysin-1Expression of inhibitorTransgenic micePAPPPregnancyCancerTransient increaseTumor-associated collagen signaturesMammary glandCollagen signaturesTumorsTransgenic expressionLactationProliferative signalingOncogeneCollagen