2017
Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53
Kenny TC, Schmidt H, Adelson K, Hoshida Y, Koh AP, Shah N, Mandeli J, Ting J, Germain D. Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53. Clinical Cancer Research 2017, 23: 5446-5459. PMID: 28630214, PMCID: PMC5600839, DOI: 10.1158/1078-0432.ccr-17-0342.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCell Line, TumorCell MovementCell ProliferationCollagenDiagnostic ImagingDisease Models, AnimalDisease SusceptibilityExtracellular FluidFemaleGene Expression ProfilingHeterograftsHumansImmunohistochemistryMiceModels, BiologicalNeoplasm GradingNeoplasm InvasivenessRetrospective StudiesTumor Suppressor Protein p53ConceptsMammary glandBilateral mastectomy patientsInvasion scoreHigh-grade primary tumorsInterstitial fluidNormal mammary glandClin Cancer ResSporadic breast cancerBreast cancer cellsVisceral metastasesSpontaneous tumor formationClinical courseDuctal hyperplasiaResidual diseaseMastectomy patientsPrimary tumorDisease progressionRadiologic examinationBreast cancerLocal invasionMouse modelCollagen depositionMyofibroblast differentiationCancer ResExtracellular matrix
2009
Wound Fluid Induces Cancer Cell Growth: A Mechanism for Recurrence?
Adelson K, Bahadur U, Halpern M, Hauptman E, Barginear M, Bleiweiss I, Ting J, Weltz C, Coomer C, Raptis G, Germain D. Wound Fluid Induces Cancer Cell Growth: A Mechanism for Recurrence? Cancer Research 2009, 69: 3146-3146. DOI: 10.1158/0008-5472.sabcs-09-3146.Peer-Reviewed Original ResearchResidual diseaseLocal recurrenceCancer cell growthBreast cancer cellsWound fluidCancer cell linesAbdominal drainMastectomy patientsSame patientCancer cellsAbdominal flap reconstructionBilateral mastectomy patientsUnilateral mastectomy patientsDifferent breast cancer cell linesBreast cancer cell linesCell linesOccult metastasesCytokine profileSurgical resectionBilateral mastectomyLymph nodesInflammatory componentUnilateral mastectomyPrimary tumorAbdominal fluid