Bortezomib Enhances the Efficacy of Fulvestrant by Promoting the Aggregation of the Estrogen Receptor in the Cytoplasm.
Germain D, Bahadur U, Halpern M, Adelson K, Raptis G, Waxman S, Ishii Y. Bortezomib Enhances the Efficacy of Fulvestrant by Promoting the Aggregation of the Estrogen Receptor in the Cytoplasm. Cancer Research 2009, 69: 5142-5142. DOI: 10.1158/0008-5472.sabcs-09-5142.Peer-Reviewed Original ResearchEfficacy of fulvestrantEstrogen receptorAromatase inhibitorsBreast cancer mouse modelPost-menopausal womenCancer mouse modelProteasome inhibitor bortezomibUnfolded protein responseEndometrial cancerPremenopausal womenFulvestrant resistanceStandard treatmentTamoxifen resistanceFulvestrant treatmentTumor regressionAgonist effectsClinical trialsBreast cancerMouse modelFulvestrantTherapeutic benefitConverts androgensAdipose tissueInhibitor bortezomibBortezomib