2010
A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma
Godshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban R, Kidd KK, Weidhaas JB, Slack FJ. A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma. Oncogene 2010, 30: 1542-1550. PMID: 21119596, PMCID: PMC3069149, DOI: 10.1038/onc.2010.536.Peer-Reviewed Original ResearchConceptsMessenger RNAsComplementary sitesNovel genetic markersKIT oncogeneTarget genesRegulatory relationshipsUntranslated regionGenetic markersHeritable riskFunctional variantsGenetic variantsOncogeneMultifaceted roleProtein levelsProtein expressionVariant resultsComplementary sequencesReporter dataUTRMelanoma pathogenesisMiR-221KIT variantsSeed regionExpressionVariants
1990
Search for the Gene for Multiple Endocrine Neoplasia Type 2A
KIDD K, SIMPSON N. Search for the Gene for Multiple Endocrine Neoplasia Type 2A. 1990, 46: 305-343. PMID: 2281187, DOI: 10.1016/b978-0-12-571146-3.50015-8.Peer-Reviewed Original ResearchConceptsMultiple endocrine neoplasia type 2AType 2AElevated hormone levelsHereditary cancer syndromesMultiple endocrine glandsSlow growingAbnormal alleleMedullary carcinomaAssociated mortalityParathyroid glandsHormone levelsUnique tissue distributionSerious symptomsTissue massCancer syndromesEndocrine glandsVital organsClinical useRisk estimatesTumorsTissue distributionC cellsElevated productionAdditional markersThyroid