2014
Application of six IrisPlex SNPs and comparison of two eye color prediction systems in diverse Eurasia populations
Yun L, Gu Y, Rajeevan H, Kidd KK. Application of six IrisPlex SNPs and comparison of two eye color prediction systems in diverse Eurasia populations. International Journal Of Legal Medicine 2014, 128: 447-453. PMID: 24395150, DOI: 10.1007/s00414-013-0953-1.Peer-Reviewed Original Research
2012
Reconstructing Native American population history
Reich D, Patterson N, Campbell D, Tandon A, Mazieres S, Ray N, Parra MV, Rojas W, Duque C, Mesa N, García LF, Triana O, Blair S, Maestre A, Dib JC, Bravi CM, Bailliet G, Corach D, Hünemeier T, Bortolini MC, Salzano FM, Petzl-Erler ML, Acuña-Alonzo V, Aguilar-Salinas C, Canizales-Quinteros S, Tusié-Luna T, Riba L, Rodríguez-Cruz M, Lopez-Alarcón M, Coral-Vazquez R, Canto-Cetina T, Silva-Zolezzi I, Fernandez-Lopez JC, Contreras AV, Jimenez-Sanchez G, Gómez-Vázquez MJ, Molina J, Carracedo Á, Salas A, Gallo C, Poletti G, Witonsky DB, Alkorta-Aranburu G, Sukernik RI, Osipova L, Fedorova SA, Vasquez R, Villena M, Moreau C, Barrantes R, Pauls D, Excoffier L, Bedoya G, Rothhammer F, Dugoujon JM, Larrouy G, Klitz W, Labuda D, Kidd J, Kidd K, Di Rienzo A, Freimer NB, Price AL, Ruiz-Linares A. Reconstructing Native American population history. Nature 2012, 488: 370-374. PMID: 22801491, PMCID: PMC3615710, DOI: 10.1038/nature11258.Peer-Reviewed Original ResearchCrohn's Disease Risk Alleles on the NOD2 Locus Have Been Maintained by Natural Selection on Standing Variation
Nakagome S, Mano S, Kozlowski L, Bujnicki JM, Shibata H, Fukumaki Y, Kidd JR, Kidd KK, Kawamura S, Oota H. Crohn's Disease Risk Alleles on the NOD2 Locus Have Been Maintained by Natural Selection on Standing Variation. Molecular Biology And Evolution 2012, 29: 1569-1585. PMID: 22319155, PMCID: PMC3697811, DOI: 10.1093/molbev/mss006.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionCrohn DiseaseGene FrequencyGenetic Predisposition to DiseaseGenotyping TechniquesHaplotypesHumansModels, GeneticModels, MolecularNod2 Signaling Adaptor ProteinPhylogenyPolymorphism, Single NucleotideProtein Structure, SecondaryProtein Structure, TertiaryRisk FactorsSelection, GeneticSequence Analysis, DNAConceptsDisease risk allelesNatural selectionCD risk allelesGenome-wide association studiesClassical linkage analysisMost recent common ancestorPhylogenetic network analysisRecent common ancestorNOD2 proteinProtein structural predictionRecent genome-wide association studiesHigh-frequency haplotypesSerious conformational changesEuropean populationsAmino acid substitutionsRisk allelesStanding variationDeleterious haplotypesEvolutionary studiesCoalescent simulationsCommon ancestorGenomic regionsNon-European populationsEntire genomeDiploid individuals
2011
The Molecular Origin and Consequences of Escape from miRNA Regulation by HLA-C Alleles
O'hUigin C, Kulkarni S, Xu Y, Deng Z, Kidd J, Kidd K, Gao X, Carrington M. The Molecular Origin and Consequences of Escape from miRNA Regulation by HLA-C Alleles. American Journal Of Human Genetics 2011, 89: 424-431. PMID: 21907013, PMCID: PMC3169826, DOI: 10.1016/j.ajhg.2011.07.024.Peer-Reviewed Original ResearchAn Application of the Elastic Net for an Endophenotype Analysis
Palejev D, Hwang W, Landi N, Eastman M, Frost SJ, Fulbright RK, Kidd JR, Kidd KK, Mason GF, Mencl WE, Yrigollen C, Pugh KR, Grigorenko EL. An Application of the Elastic Net for an Endophenotype Analysis. Behavior Genetics 2011, 41: 120-124. PMID: 21229297, PMCID: PMC3613288, DOI: 10.1007/s10519-011-9443-8.Peer-Reviewed Original Research
2010
Using a Pharmacokinetic Model to Relate an Individual’s Susceptibility to Alcohol Dependence to Genotypes
Mustavich LF, Miller P, Kidd KK, Zhao H. Using a Pharmacokinetic Model to Relate an Individual’s Susceptibility to Alcohol Dependence to Genotypes. Human Heredity 2010, 70: 177-193. PMID: 20714161, PMCID: PMC3164201, DOI: 10.1159/000317056.Peer-Reviewed Original ResearchConceptsMolecular levelStatistical gene-gene interactionsTissues of individualsGenetic variationGene-gene interactionsMolecular mechanismsGenesParticular genotypeHaplotype frequenciesPopulation levelGenotype effectsDisease riskIndividual susceptibilityMechanistic modelGenotypesADH7SusceptibilityCommon diseaseMechanistic modelingInteractionADH1CALDH2ADH1BStatistical interactionTAS2R38
2004
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang E, Ding Y, Flodman P, Kidd J, Kidd K, Grady D, Ryder O, Spence M, Swanson J, Moyzis R. The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus. American Journal Of Human Genetics 2004, 74: 931-944. PMID: 15077199, PMCID: PMC1181986, DOI: 10.1086/420854.Peer-Reviewed Original ResearchConceptsLittle linkage disequilibriumHuman dopamine receptor D4 genePolymorphic sitesDNA sequence organizationMost polymorphic sitesPatterns of recombinationObserved LD patternRare mutational eventsDRD4 locusGenetic architectureHaplotype diversityPositive selectionMore polymorphismsSequence organizationGene locusTandem repeatsMutational eventsLD patternsLinkage disequilibriumDopamine receptor D4 geneLociPhysiological differencesSame alleleReceptor variantsAlleles
2000
Haplotype Evolution and Linkage Disequilibrium: A Simulation Study
Calafell F, Grigorenko E, Chikanian A, Kidd K. Haplotype Evolution and Linkage Disequilibrium: A Simulation Study. Human Heredity 2000, 51: 85-96. PMID: 11096275, DOI: 10.1159/000022963.Peer-Reviewed Original Research
1998
Network Analyses of Y-Chromosomal Types in Europe, Northern Africa, and Western Asia Reveal Specific Patterns of Geographic Distribution
Malaspina P, Cruciani F, Ciminelli B, Terrenato L, Santolamazza P, Alonso A, Banyko J, Brdicka R, García O, Gaudiano C, Guanti G, Kidd K, Lavinha J, Avila M, Mandich P, Moral P, Qamar R, Mehdi S, Ragusa A, Stefanescu G, Caraghin M, Tyler-Smith C, Scozzari R, Novelletto A. Network Analyses of Y-Chromosomal Types in Europe, Northern Africa, and Western Asia Reveal Specific Patterns of Geographic Distribution. American Journal Of Human Genetics 1998, 63: 847-860. PMID: 9718330, PMCID: PMC1377388, DOI: 10.1086/301999.Peer-Reviewed Original ResearchConceptsExtant human populationsTotal diversityChromosomal lineagesLength variantsDinucleotide microsatellitesY chromosomeCommon descentPhenetic relationshipsGeographic distributionNorthern AfricaHaplotypesHuman populationLineagesDinucleotide unitsRapid generationDiversityWestern AsiaNetwork analysisChromosomesMicrosatellitesSpecific patternsOptimal markerReliable frequency estimatesMutationsExtinctionGenetic Structure of the Ancestral Population of Modern Humans
Ziętkiewicz E, Yotova V, Jarnik M, Korab-Laskowska M, Kidd K, Modiano D, Scozzari R, Stoneking M, Tishkoff S, Batzer M, Labuda D. Genetic Structure of the Ancestral Population of Modern Humans. Journal Of Molecular Evolution 1998, 47: 146-155. PMID: 9694663, DOI: 10.1007/pl00006371.Peer-Reviewed Original ResearchConceptsNucleotide diversityAncestral populationsNeutral DNA polymorphismsOverall nucleotide diversityPopulation-specific variantsOld polymorphismsGenetic structureAncestral stateHuman divergenceOrthologous sitesGenetic variabilityDNA polymorphismsNew allelesHuman variantsPolymorphic sitesNon-AfricansWorldwide sampleGreat apesEffective sizeModern humansHuman groupsDiversityPolymorphismDivergenceNew Guinea
1997
Editorial: Can we find genes for schizophrenia?
Kidd K. Editorial: Can we find genes for schizophrenia? American Journal Of Medical Genetics 1997, 74: 104-111. PMID: 9034016, DOI: 10.1002/(sici)1096-8628(19970221)74:1<104::aid-ajmg21>3.0.co;2-u.Peer-Reviewed Original Research
1996
Dynamics of the haplotype frequencies in populations: study using the Monte Carlo method.
Grigorenko E, Shikanian A, Kidd D, Dorig R, Kidd K. Dynamics of the haplotype frequencies in populations: study using the Monte Carlo method. Genetika 1996, 32: 1705-13. PMID: 9102365.Peer-Reviewed Original ResearchConceptsNatural selectionEffective population sizeRandom genetic driftMonte Carlo methodHaplotype frequenciesGenetic driftRandom matingEvolutionary dynamicsCarlo methodPopulation sizeRecurrent mutationsMutation processHarmonic meanFrequency dynamicsDifferent populationsSimulation resultsExperimental dataDynamicsMatingPopulationMutationsHaplotypesAllelesColonizationNew World colonizationMinisatellite diversity supports a recent African origin for modern humans
Armour J, Anttinen T, May C, Vega E, Sajantila A, Kidd J, Kidd K, Bertranpetit J, Pääbo S, Jeffreys A. Minisatellite diversity supports a recent African origin for modern humans. Nature Genetics 1996, 13: 154-160. PMID: 8640220, DOI: 10.1038/ng0696-154.Peer-Reviewed Original ResearchConceptsRecent African originNon-African populationsModern human diversityAllelic diversityMinisatellite diversityVariable lociAncestral relationshipsHuman chromosomesAllelic structureAfrican originGreat diversityDiversityHuman diversityAfrican chromosomesChromosomesAllele familiesLociModern humansDifferent populationsNo association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations
Lu R, Ko H, Chang F, Castiglione C, Schoolfield G, Pakstis A, Kidd J, Kidd K. No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations. Biological Psychiatry 1996, 39: 419-429. PMID: 8679787, DOI: 10.1016/0006-3223(95)00182-4.Peer-Reviewed Original Research
1995
Internet-based Support for Bioscience Research: A Collaborative Genome center for Human Chromosome 12
Miller P, Nadkarni P, Kidd K, Cheung K, Ward D, Banks A, Bray-Ward P, Cupelli L, Herdman V, Marondel I, Montcomery K, Renault B, Yoon S, Krauter K, Kucherlapati R. Internet-based Support for Bioscience Research: A Collaborative Genome center for Human Chromosome 12. Journal Of The American Medical Informatics Association 1995, 2: 351-364. PMID: 8581551, PMCID: PMC116278, DOI: 10.1136/jamia.1995.96157828.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Artificial, YeastChromosomes, Human, Pair 12Computer Communication NetworksConnecticutData DisplayDatabases, FactualGenetic MarkersGenome, HumanHumansInterinstitutional RelationsLocal Area NetworksModels, GeneticNew York CityOrganizational ObjectivesSoftware DesignSystems IntegrationUser-Computer InterfaceConceptsUser-friendly front endInternet-based supportExternal databasesMedical informaticsGenome CenterGenome informaticsDatabase programMapping communityCandidate mapsInformaticsAssembly toolsAreas of bioscienceFront endDatabaseServerSybaseSuch supportCase studySetToolBioscience researchCertain issuesClientsTechnologySupport
1994
Progress in a genome scan for linkage in schizophrenia in a large Swedish kindred
Barr C, Kennedy J, Pakstis A, Wetterberg L, Sjögren B, Bierut L, Wadelius C, Wahlström J, Martinsson T, Giuffra L, Gelernter J, Hallmayer J, Moises H, Kurth J, Cavalli‐Sforza L, Kidd K. Progress in a genome scan for linkage in schizophrenia in a large Swedish kindred. American Journal Of Medical Genetics 1994, 54: 51-58. PMID: 7909991, DOI: 10.1002/ajmg.1320540110.Peer-Reviewed Original ResearchLinkage Study of a Susceptibility Locus for Schizophrenia in the Pseudoautosomal Region
Barr C, Kennedy J, Pakstis A, Castiglione C, Kidd J, Wetterberg L, Kidd K. Linkage Study of a Susceptibility Locus for Schizophrenia in the Pseudoautosomal Region. Schizophrenia Bulletin 1994, 20: 277-286. PMID: 8085132, DOI: 10.1093/schbul/20.2.277.Peer-Reviewed Original Research
1991
Modeling uncertainty in a database for physical gene mapping data.
Miller P, Shifman M, Kidd K. Modeling uncertainty in a database for physical gene mapping data. AMIA Annual Symposium Proceedings 1991, 409-13. PMID: 1807633, PMCID: PMC2247564.Peer-Reviewed Original Research
1990
Segregation and Linkage Analyses of Tourette's Syndrome and Related Disorders
PAULS D, PAKSTIS A, KURLAN R, KIDD K, LECKMAN J, COHEN D, KIDD J, COMO P, SPARKES R. Segregation and Linkage Analyses of Tourette's Syndrome and Related Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 1990, 29: 195-203. PMID: 2324061, DOI: 10.1097/00004583-199003000-00007.Peer-Reviewed Original Research
1989
Estimation of segregation and linkage parameters in simulated data. I. Segregation analyses with different ascertainment schemes.
Kramer P, Pauls D, Price R, Kidd K. Estimation of segregation and linkage parameters in simulated data. I. Segregation analyses with different ascertainment schemes. American Journal Of Human Genetics 1989, 45: 83-94. PMID: 2741953, PMCID: PMC1683375.Peer-Reviewed Original ResearchConceptsBetter parameter estimatesDifferent sampling schemesGenetic model parametersParameter estimatesSampling schemeModel parametersLinkage parametersHeterozygote penetranceSimulation studyDifferent ascertainment schemesAnalysis packagePedigree Analysis PackageSchemeInformation lossData setsParametersSample sizeModel