1996
Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia, type IIA: Implications for therapy
Gill J, Reyes-Múgica M, Iyengar S, Kidd K, Touloukian R, Smith C, Keller M, Genel M. Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia, type IIA: Implications for therapy. The Journal Of Pediatrics 1996, 129: 459-464. PMID: 8804341, DOI: 10.1016/s0022-3476(96)70084-7.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, MedullaryChildChild, PreschoolFemaleHumansLymph NodesLymphatic MetastasisMultiple Endocrine Neoplasia Type 2aThyroid NeoplasmsThyroidectomyConceptsMedullary thyroid carcinomaMultiple endocrine neoplasiaEndocrine neoplasiaThyroid carcinomaMultifocal medullary thyroid carcinomaMetastatic medullary carcinomaElevated calcitonin levelsC-cell hyperplasiaType IIaAge 1 yearYears of ageYears 8 monthsYears 11 monthsIIA patientsLymph nodesCalcitonin levelsProphylactic thyroidectomyMedullary carcinomaStimulation testEarly presentationPositive findingsCarcinomaThyroidectomyNeoplasiaAge
1993
Genomic and Yeast Artificial Chromosome Long-Range Regular Article Linking Six Loci in 10q11.2 and Spanning the Multiple Endocrine Neoplasia Type 2A (MEN2A) Region
Brooks-Wilson A, Lichter J, Ward D, Kidd K, Goodfellow P. Genomic and Yeast Artificial Chromosome Long-Range Regular Article Linking Six Loci in 10q11.2 and Spanning the Multiple Endocrine Neoplasia Type 2A (MEN2A) Region. Genomics 1993, 17: 611-617. PMID: 7902324, DOI: 10.1006/geno.1993.1380.Peer-Reviewed Original ResearchConceptsRestriction mappingIdentification of genesLong-range restriction mappingContig assemblyPhysical mapTumor-specific alterationsGenomic DNAYAC contigPhysical linkageCandidate intervalDistal lociLociProto-oncogeneD10S102GenesCandidate regionsRET proto-oncogeneFamilial medullary thyroid carcinomaType 2ARETD10S94Multiple endocrine neoplasia type 2AContigsGenomicsHereditary cancer