2014
Maritime route of colonization of Europe
Paschou P, Drineas P, Yannaki E, Razou A, Kanaki K, Tsetsos F, Padmanabhuni SS, Michalodimitrakis M, Renda MC, Pavlovic S, Anagnostopoulos A, Stamatoyannopoulos JA, Kidd KK, Stamatoyannopoulos G. Maritime route of colonization of Europe. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 9211-9216. PMID: 24927591, PMCID: PMC4078858, DOI: 10.1073/pnas.1320811111.Peer-Reviewed Original ResearchMeSH KeywordsEmigration and ImmigrationFemaleGene FlowGenetics, MedicalGenome-Wide Association StudyHistory, AncientHumansMaleMediterranean RegionPolymorphism, GeneticConceptsSouthern European coastsGene flowGenome-wide DNA polymorphismsEuropean coastsWest clineDNA polymorphismsNeolithic farmersCoastal routeMediterranean SeaNetwork analysisMediterranean coastMainland EuropeNeolithic populationsCentral EuropeClineCoastGenesColonizationNear EastStriking structurePolymorphismPopulationAnatoliaHypothesisIslands
2012
Structural diversity and African origin of the 17q21.31 inversion polymorphism
Steinberg KM, Antonacci F, Sudmant PH, Kidd JM, Campbell CD, Vives L, Malig M, Scheinfeldt L, Beggs W, Ibrahim M, Lema G, Nyambo TB, Omar SA, Bodo JM, Froment A, Donnelly MP, Kidd KK, Tishkoff SA, Eichler EE. Structural diversity and African origin of the 17q21.31 inversion polymorphism. Nature Genetics 2012, 44: 872-880. PMID: 22751100, PMCID: PMC3408829, DOI: 10.1038/ng.2335.Peer-Reviewed Original Research
2011
ALFRED: an allele frequency resource for research and teaching
Rajeevan H, Soundararajan U, Kidd JR, Pakstis AJ, Kidd KK. ALFRED: an allele frequency resource for research and teaching. Nucleic Acids Research 2011, 40: d1010-d1015. PMID: 22039151, PMCID: PMC3245092, DOI: 10.1093/nar/gkr924.Peer-Reviewed Original ResearchSelection on the Human Bitter Taste Gene, TAS2R16, in Eurasian Populations
Li H, Pakstis AJ, Kidd JR, Kidd KK. Selection on the Human Bitter Taste Gene, TAS2R16, in Eurasian Populations. Human Biology 2011, 83: 363-377. PMID: 21740153, DOI: 10.3378/027.083.0303.Peer-Reviewed Original ResearchDiversification of the ADH1B Gene during Expansion of Modern Humans
Li H, Gu S, Han Y, Xu Z, Pakstis AJ, Jin L, Kidd JR, Kidd KK. Diversification of the ADH1B Gene during Expansion of Modern Humans. Annals Of Human Genetics 2011, 75: 497-507. PMID: 21592108, PMCID: PMC3722864, DOI: 10.1111/j.1469-1809.2011.00651.x.Peer-Reviewed Original ResearchConceptsShort tandem repeat polymorphismsSingle nucleotide polymorphismsGeographic patternsAncient DNA samplesADH1B geneSelective forcesRegulatory region variantsUnusual geographic distributionMigration eventsCommon haplogroupsDistinct geographic patternsGeographic distributionGenesNucleotide polymorphismsEast Asian populationsTandem repeat polymorphismDNA samplesHaplogroupsWorldwide setAllelesModern humansRegion variantsRepeat polymorphismPolymorphismEast Asia
2010
A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is less common in the Quechua, a high altitude Native population.
Wang P, Ha AY, Kidd KK, Koehle MS, Rupert JL. A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is less common in the Quechua, a high altitude Native population. High Altitude Medicine & Biology 2010, 11: 27-30. PMID: 20367485, DOI: 10.1089/ham.2009.1054.Peer-Reviewed Original ResearchConceptsHigh-altitude pulmonary edemaEndothelial nitric oxide synthaseAcute mountain sicknessNitric oxideG alleleEndothelial nitric oxide synthase geneAltitude-related illnessesG894T polymorphismNitric oxide synthase geneNitric oxide synthaseAltitude pulmonary edemaOxide synthase geneNOS3 genotypesPulmonary edemaOxide synthaseVascular enzymeMountain sicknessT polymorphismBlood flowAltitude toleranceNOS3AMS susceptibilityHypoxic environmentHigh-altitude native populationsEnvironmental hypoxia
2004
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang E, Ding Y, Flodman P, Kidd J, Kidd K, Grady D, Ryder O, Spence M, Swanson J, Moyzis R. The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus. American Journal Of Human Genetics 2004, 74: 931-944. PMID: 15077199, PMCID: PMC1181986, DOI: 10.1086/420854.Peer-Reviewed Original ResearchConceptsLittle linkage disequilibriumHuman dopamine receptor D4 genePolymorphic sitesDNA sequence organizationMost polymorphic sitesPatterns of recombinationObserved LD patternRare mutational eventsDRD4 locusGenetic architectureHaplotype diversityPositive selectionMore polymorphismsSequence organizationGene locusTandem repeatsMutational eventsLD patternsLinkage disequilibriumDopamine receptor D4 geneLociPhysiological differencesSame alleleReceptor variantsAlleles
2003
Genetic Polymorphisms in the Renin‐Angiotensin System in High‐Altitude and Low‐Altitude Native American Populations
Rupert J, Kidd K, Norman L, Monsalve M, Hochachka P, Devine D. Genetic Polymorphisms in the Renin‐Angiotensin System in High‐Altitude and Low‐Altitude Native American Populations. Annals Of Human Genetics 2003, 67: 17-25. PMID: 12556231, DOI: 10.1046/j.1469-1809.2003.00004.x.Peer-Reviewed Original Research
2001
Insertional polymorphisms of full-length endogenous retroviruses in humans
Turner G, Barbulescu M, Su M, Jensen-Seaman M, Kidd K, Lenz J. Insertional polymorphisms of full-length endogenous retroviruses in humans. Current Biology 2001, 11: 1531-1535. PMID: 11591322, DOI: 10.1016/s0960-9822(01)00455-9.Peer-Reviewed Original Research
2000
Worldwide Genetic Analysis of the CFTR Region
Mateu E, Calafell F, Lao O, Bonné-Tamir B, Kidd J, Pakstis A, Kidd K, Bertranpetit J. Worldwide Genetic Analysis of the CFTR Region. American Journal Of Human Genetics 2000, 68: 103-117. PMID: 11104661, PMCID: PMC1234903, DOI: 10.1086/316940.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulator (CFTR) geneShort tandem repeat polymorphismsSingle nucleotide polymorphismsLinkage disequilibriumHaplotype backgroundTransmembrane conductance regulator geneWorldwide population samplesModern human populationsHaplotype variationHigh heterozygosityCFTR regionOut of AfricaRegulator geneSevere genetic disorderGenetic analysisMutation rateDifferent haplotypesAncestral haplotypeAllele sizeOutcome of differencesSNP haplotypesLD analysisNon-AfricansHaplotypesLD measuresSequence variability and candidate gene analysis in complex disease: association of µ opioid receptor gene variation with substance dependence
Hoehe M, Köpke K, Wendel B, Rohde K, Flachmeier C, Kidd K, Berrettini W, Church G. Sequence variability and candidate gene analysis in complex disease: association of µ opioid receptor gene variation with substance dependence. Human Molecular Genetics 2000, 9: 2895-2908. PMID: 11092766, DOI: 10.1093/hmg/9.19.2895.Peer-Reviewed Original ResearchConceptsComplex genotype-phenotype relationshipsGenotype-phenotype relationshipsCandidate genesSequence variabilitySequence variantsGene sequence informationDNA sequence variationCandidate gene analysisSpecific sequence variantsPrime candidate geneCombination of variantsSequence comparisonSequence variationSequence informationHuman mu-opioid receptor geneDifferent haplotypesGene analysisGenesComplex diseasesReceptor geneOpioid receptor geneHaplotypesGene variationMultiple individualsModel systemShort Tandem-Repeat Polymorphism/Alu Haplotype Variation at the PLAT Locus: Implications for Modern Human Origins
Tishkoff S, Pakstis A, Stoneking M, Kidd J, Destro-Bisol G, Sanjantila A, Lu R, Deinard A, Sirugo G, Jenkins T, Kidd K, Clark A. Short Tandem-Repeat Polymorphism/Alu Haplotype Variation at the PLAT Locus: Implications for Modern Human Origins. American Journal Of Human Genetics 2000, 67: 901-925. PMID: 10986042, PMCID: PMC1287905, DOI: 10.1086/303068.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaAllelesAlu ElementsAnimalsChromosomes, Human, Pair 8Dinucleotide RepeatsEvolution, MolecularGene FrequencyGenetic VariationHaplotypesHominidaeHumansLinkage DisequilibriumMicronesiaPapua New GuineaPhylogenyPolymorphism, GeneticSequence DeletionTandem Repeat SequencesConceptsNon-African populationsHaplotype variationGene flowLinkage disequilibriumShort tandem repeat polymorphismsHaplotype diversityPLAT locusLarge effective population sizesAncient gene flowEffective population sizeDinucleotide short tandem repeat polymorphismsRecent common ancestryAlu insertion/deletion polymorphismHuman evolutionary historyDiverse human populationsModern human originsEvolutionary historyCommon ancestryAfrican populationsPopulation substructureAlu elementsPolymorphic Alu elementsPopulation sizeRare haplotypesDinucleotide repeatsThe Accuracy of Statistical Methods for Estimation of Haplotype Frequencies: An Example from the CD4 Locus
Tishkoff S, Pakstis A, Ruano G, Kidd K. The Accuracy of Statistical Methods for Estimation of Haplotype Frequencies: An Example from the CD4 Locus. American Journal Of Human Genetics 2000, 67: 518-522. PMID: 10859209, PMCID: PMC1287198, DOI: 10.1086/303000.Peer-Reviewed Original ResearchHaplotypes and Linkage Disequilibrium at the Phenylalanine Hydroxylase Locus, PAH, in a Global Representation of Populations
Kidd J, Pakstis A, Zhao H, Lu R, Okonofua F, Odunsi A, Grigorenko E, Tamir B, Friedlaender J, Schulz L, Parnas J, Kidd K. Haplotypes and Linkage Disequilibrium at the Phenylalanine Hydroxylase Locus, PAH, in a Global Representation of Populations. American Journal Of Human Genetics 2000, 66: 1882-1899. PMID: 10788337, PMCID: PMC1378054, DOI: 10.1086/302952.Peer-Reviewed Original ResearchEvolution of exon 1 of the dopamine D4 receptor (DRD4) gene in primates
Seaman M, Chang F, Deinard A, Quiñones A, Kidd K. Evolution of exon 1 of the dopamine D4 receptor (DRD4) gene in primates. Journal Of Experimental Zoology 2000, 288: 32-38. PMID: 10750051, DOI: 10.1002/(sici)1097-010x(20000415)288:1<32::aid-jez4>3.0.co;2-g.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionDNA Mutational AnalysisExonsHumansPolymorphism, GeneticPrimatesReceptors, DopamineConceptsHigh conservationOld World monkeysWorld monkeysTandem repeatsPrimate speciesExon 1Amino acid sequenceReceptor geneGreat apesRelaxed selectionEvolutionary historyD4 receptor geneHomologous exonsInterspecific differencesNew World monkeysDopamine D4 receptor geneAcid sequenceSelective pressureFirst exonTandem duplicationExonsExon 3SpeciesGenesRepeats
1999
Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4)
Seaman M, Fisher J, Chang F, Kidd K. Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4). American Journal Of Medical Genetics 1999, 88: 705-709. PMID: 10581493, DOI: 10.1002/(sici)1096-8628(19991215)88:6<705::aid-ajmg22>3.0.co;2-f.Peer-Reviewed Original ResearchAllelesAnimalsCodon, InitiatorConsensus SequenceDatabases, FactualEvolution, MolecularGene FrequencyGenetic VariationGorilla gorillaHumansPan troglodytesPolymorphism, GeneticPongo pygmaeusReceptors, Dopamine D2Receptors, Dopamine D4Response ElementsSequence Homology, Nucleic AcidTandem Repeat SequencesTranscription FactorsEvolution of the HOXB6 intergenic region: Motif conservation at the lateral plate mesoderm (LPM) enhancer element
Deinard A, Dorit R, Castiglione C, Jiang Z, Becker D, Ruddle F, Schugart K, Kidd K. Evolution of the HOXB6 intergenic region: Motif conservation at the lateral plate mesoderm (LPM) enhancer element. Journal Of Experimental Zoology 1999, 285: 170-176. PMID: 10440728, DOI: 10.1002/(sici)1097-010x(19990815)285:2<170::aid-jez9>3.0.co;2-j.Peer-Reviewed Original ResearchGlobal variation of a 40-bp VNTR in the 3′-untranslated region of the dopamine transporter gene (SLC6A3)
Kang A, Palmatier M, Kidd K. Global variation of a 40-bp VNTR in the 3′-untranslated region of the dopamine transporter gene (SLC6A3). Biological Psychiatry 1999, 46: 151-160. PMID: 10418689, DOI: 10.1016/s0006-3223(99)00101-8.Peer-Reviewed Original ResearchY‐chromosome specific YCAII, DYS19 and YAP polymorphisms in human populations: a comparative study
QUINTANA‐MURCI L, SEMINO O, POLONI E, LIU A, VAN GIJN M, PASSARINO G, BREGA A, NASIDZE I, MACCIONI L, COSSU G, AL‐ZAHERY N, KIDD J, KIDD K, SANTACHIARA‐BENERECETTI A. Y‐chromosome specific YCAII, DYS19 and YAP polymorphisms in human populations: a comparative study. Annals Of Human Genetics 1999, 63: 153-166. PMID: 10738527, DOI: 10.1046/j.1469-1809.1999.6320153.x.Peer-Reviewed Original ResearchConceptsY Alu PolymorphismGenetic structureGenetic affinityStrong genetic structurePopulation genetic structureAlu polymorphismsY markersHuman populationYCAIIDifferent populationsRelated groupsPolymorphismSpecific markersPopulationMarkersDYS19Geographic locationDifferent statistical analysesFrequency distributionSTRAffinityAllele Frequencies in a Worldwide Survey of a CA Repeat in the First Intron of the CFTR Gene
Mateu E, Calafell F, Bonné-Tamir B, Kidd J, Casals T, Kidd K, Bertranpetit J. Allele Frequencies in a Worldwide Survey of a CA Repeat in the First Intron of the CFTR Gene. Human Heredity 1999, 49: 15-20. PMID: 9858852, DOI: 10.1159/000022834.Peer-Reviewed Original ResearchConceptsCFTR geneIntron 1Allele frequenciesMolecular varianceGenetic varianceFirst intronDinucleotide CACA repeatsGenesCF mutationsHaplotypic analysisMutationsMajor geographical areasAfrican populationsUnknown mutationsAllele distributionPolymorphismCystic fibrosisIntronsChromosomesRepeatsGeographical regionsLociHeterozygosityPopulation