2024
CYP2C gene polymorphisms in North African populations
Messaoudi M, Pakstis A, Boussetta S, Ben Ammar Elgaaied A, Kidd K, Cherni L. CYP2C gene polymorphisms in North African populations. Molecular Biology Reports 2024, 51: 1145. PMID: 39532754, DOI: 10.1007/s11033-024-10093-8.Peer-Reviewed Original ResearchConceptsNorth African populationsCYP2C genesHuman CYP2C genesSuperfamily of genesAfrican populationsRegulatory regionsIntronic SNPGenetic variationHaplotype frequenciesChromosome 10Pharmacogenetic markersFunctional consequencesGenesResponse to medical treatmentSNPsTunisian populationCYP2C9Drug metabolismForeign chemicalsCYP2C19North AfricansBackgroundCytochrome P450Clinically useful drugsGene polymorphismsPrincipal component analysis
2021
STAT3 polymorphisms in North Africa and its implication in breast cancer
Ziadi W, Boussetta S, Elkamel S, Pakstis AJ, Kidd KK, Medimegh I, Elgaaied A, Cherni L. STAT3 polymorphisms in North Africa and its implication in breast cancer. Molecular Genetics & Genomic Medicine 2021, 9: e1744. PMID: 34251094, PMCID: PMC8404238, DOI: 10.1002/mgg3.1744.Peer-Reviewed Original ResearchConceptsNorth African populationsAfrican populationsSTAT3 regionSingle nucleotide polymorphismsRare haplotypesHsa-mirMiR databaseMajor haplotypesGenesNucleotide polymorphismsHaplotypesSNPsSTAT3Allele frequenciesRs7211777Tunisian populationPolymorphismPopulationDiversityNorth AfricaAllelesSignificant frequencyRecombinationAssaysCancer