Drug response as a predictor of transmission of non-bipolar major depression within families
Prusoff B, Weissman M, Merikangas K, Leckman J, Kidd K. Drug response as a predictor of transmission of non-bipolar major depression within families. Journal Of Affective Disorders 1985, 8: 171-176. PMID: 3157727, DOI: 10.1016/0165-0327(85)90041-2.Peer-Reviewed Original ResearchConceptsNon-bipolar major depressionMajor depressionAffective illnessFirst-degree relativesTermination of treatmentRelatives of probandsClinical responsePharmacological therapyPoor responseClinical trialsSomatic treatmentsDistinct subtypesPredictors of transmissionFirst weekDrug responseFamilial aggregationRapid improvementDepressionProbandsHigh rateIllnessSubtypesTreatmentResponseTherapy