2010
Using a Pharmacokinetic Model to Relate an Individual’s Susceptibility to Alcohol Dependence to Genotypes
Mustavich LF, Miller P, Kidd KK, Zhao H. Using a Pharmacokinetic Model to Relate an Individual’s Susceptibility to Alcohol Dependence to Genotypes. Human Heredity 2010, 70: 177-193. PMID: 20714161, PMCID: PMC3164201, DOI: 10.1159/000317056.Peer-Reviewed Original ResearchConceptsMolecular levelStatistical gene-gene interactionsTissues of individualsGenetic variationGene-gene interactionsMolecular mechanismsGenesParticular genotypeHaplotype frequenciesPopulation levelGenotype effectsDisease riskIndividual susceptibilityMechanistic modelGenotypesADH7SusceptibilityCommon diseaseMechanistic modelingInteractionADH1CALDH2ADH1BStatistical interactionTAS2R38
1978
Research Designs for the Study of Gene-Environment Interactions in Psychiatric Disorders: Report of a Foundations Fund for Research in Psychiatry Panel
Kidd K, Matthysee S. Research Designs for the Study of Gene-Environment Interactions in Psychiatric Disorders: Report of a Foundations Fund for Research in Psychiatry Panel. JAMA Psychiatry 1978, 35: 925-932. PMID: 678045, DOI: 10.1001/archpsyc.1978.01770320019001.Peer-Reviewed Original ResearchConceptsGenetic variantsUnrelated individualsIndividual genetic variantsGenetic variationDifferent genetic variantsExtended pedigreesGenetic heterogeneityGene-environment interactionsGenetic hypothesisPhenotypeDiagnostic phenotypesFamilyGeneticsVariantsTraitsIndividual susceptibilitySpecific hypothesesSuch studiesHypothesisEnvironmental contributionsPedigreeGenotypesSusceptibility