1989
Estimation of segregation and linkage parameters in simulated data. I. Segregation analyses with different ascertainment schemes.
Kramer P, Pauls D, Price R, Kidd K. Estimation of segregation and linkage parameters in simulated data. I. Segregation analyses with different ascertainment schemes. American Journal Of Human Genetics 1989, 45: 83-94. PMID: 2741953, PMCID: PMC1683375.Peer-Reviewed Original ResearchConceptsBetter parameter estimatesDifferent sampling schemesGenetic model parametersParameter estimatesSampling schemeModel parametersLinkage parametersHeterozygote penetranceSimulation studyDifferent ascertainment schemesAnalysis packagePedigree Analysis PackageSchemeInformation lossData setsParametersSample sizeModel
1987
Early Onset (Under Age 30 Years) and Panic Disorder as Markers for Etiologic Homogeneity in Major Depression
Price R, Kidd K, Weissman M. Early Onset (Under Age 30 Years) and Panic Disorder as Markers for Etiologic Homogeneity in Major Depression. JAMA Psychiatry 1987, 44: 434-440. PMID: 3472494, DOI: 10.1001/archpsyc.1987.01800170048008.Peer-Reviewed Original ResearchConceptsEarly onsetMajor depressionPanic disorderLate-onset depressionPrevalence of depressionElevation of riskFamilies of probandsYale Family StudyEtiologic homogeneityHigh riskPatterns of transmissionOlder age cohortsRestriction of analysisDepressionPopulation ratesFamily studiesProbandsOnsetDisordersAge cohortsRiskGenetic modelsSample sizeCohortPrevalence