2000
Sequence variability and candidate gene analysis in complex disease: association of µ opioid receptor gene variation with substance dependence
Hoehe M, Köpke K, Wendel B, Rohde K, Flachmeier C, Kidd K, Berrettini W, Church G. Sequence variability and candidate gene analysis in complex disease: association of µ opioid receptor gene variation with substance dependence. Human Molecular Genetics 2000, 9: 2895-2908. PMID: 11092766, DOI: 10.1093/hmg/9.19.2895.Peer-Reviewed Original ResearchConceptsComplex genotype-phenotype relationshipsGenotype-phenotype relationshipsCandidate genesSequence variabilitySequence variantsGene sequence informationDNA sequence variationCandidate gene analysisSpecific sequence variantsPrime candidate geneCombination of variantsSequence comparisonSequence variationSequence informationHuman mu-opioid receptor geneDifferent haplotypesGene analysisGenesComplex diseasesReceptor geneOpioid receptor geneHaplotypesGene variationMultiple individualsModel system
1996
Conserved regulatory element involved in the early onset of Hoxb6 gene expression
Becker D, Jiang Z, Knödler P, Deinard A, Eid R, Kidd K, Shashikant C, Ruddle F, Schughart K. Conserved regulatory element involved in the early onset of Hoxb6 gene expression. Developmental Dynamics 1996, 205: 73-81. PMID: 8770553, DOI: 10.1002/(sici)1097-0177(199601)205:1<73::aid-aja7>3.0.co;2-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceConserved SequenceDNADNA PrimersEmbryonic and Fetal DevelopmentEnhancer Elements, GeneticGene Expression Regulation, DevelopmentalGenes, HomeoboxGenes, RegulatorGenes, ReporterHomeodomain ProteinsHumansIn Situ HybridizationMesodermMiceMice, TransgenicMolecular Sequence DataSequence Homology, Nucleic AcidConceptsGene expressionPosterior lateral plate mesodermConserved regulatory elementsLateral plate mesodermReporter gene analysisSimilar enhancer activityHuman DNA sequencesBp DNA fragmentMammalian embryosMouse developmentPlate mesodermRegulatory elementsDNA sequencesEnhancer activityExpression patternsDNA fragmentsGene analysisEnhancerTransgenic miceExpressionInitial activationEarly stagesMesodermEmbryosTransgene