2004
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang E, Ding Y, Flodman P, Kidd J, Kidd K, Grady D, Ryder O, Spence M, Swanson J, Moyzis R. The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus. American Journal Of Human Genetics 2004, 74: 931-944. PMID: 15077199, PMCID: PMC1181986, DOI: 10.1086/420854.Peer-Reviewed Original ResearchConceptsLittle linkage disequilibriumHuman dopamine receptor D4 genePolymorphic sitesDNA sequence organizationMost polymorphic sitesPatterns of recombinationObserved LD patternRare mutational eventsDRD4 locusGenetic architectureHaplotype diversityPositive selectionMore polymorphismsSequence organizationGene locusTandem repeatsMutational eventsLD patternsLinkage disequilibriumDopamine receptor D4 geneLociPhysiological differencesSame alleleReceptor variantsAlleles
1993
A hypervariable segment in the human dopamine receptor D4 (DRD4) gene
Lichter J, Barr C, Kennedy J, Van Tol H, Kidd K, Livak K. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics 1993, 2: 767-773. PMID: 8353495, DOI: 10.1093/hmg/2.6.767.Peer-Reviewed Original ResearchConceptsHuman dopamine receptor D4 geneAmino acid sequenceThird cytoplasmic loopNumber of repeatsPutative third cytoplasmic loopFunctional proteinsCytoplasmic loopAcid sequenceRepeat regionDifferent repeatsHypervariable segmentDifferent haplotypesRepeatsDopamine receptor D4 geneUnrelated chromosomesNovel polymorphismsD4 geneGenesProteinHuman dopamine D4 receptorPolymorphic variantsSequencePolymorphismChromosomesReceptors