Predicting genotypes at loci for autosomal recessive disorders using linked genetic markers: application to Wilson's disease
Farrer L, Bonne-Tamir B, Frydman M, Magazanik A, Kidd K, Bowcock A, Cavalli-Sforza L. Predicting genotypes at loci for autosomal recessive disorders using linked genetic markers: application to Wilson's disease. Human Genetics 1988, 79: 109-117. PMID: 3164701, DOI: 10.1007/bf00280547.Peer-Reviewed Original ResearchConceptsWilson disease locusDisease locusUnaffected individualsChromosome 13 markersWND locusMultipoint linkage analysisDisease familiesWilson disease familiesGenetic markersLinkage analysisChromosome 13Long armLociSources of variationAutosomal recessive disorderMore variationGenotypesCopper concentrationRecessive disorderNormal homozygotesWilson's diseaseFamilial componentMarkersCopper levelsSubsequent analysis