1999
Linkage Disequilibrium at the ADH2 and ADH3 Loci and Risk of Alcoholism
Osier M, Pakstis A, Kidd J, Lee J, Yin S, Ko H, Edenberg H, Lu R, Kidd K. Linkage Disequilibrium at the ADH2 and ADH3 Loci and Risk of Alcoholism. American Journal Of Human Genetics 1999, 64: 1147-1157. PMID: 10090900, PMCID: PMC1377839, DOI: 10.1086/302317.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DehydrogenaseAlcoholismAllelesBase SequenceChinaChromosomes, Human, Pair 4Cloning, MolecularGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHaplotypesHumansIndians, Central AmericanLinkage DisequilibriumMexicoMolecular Sequence DataMultigene FamilyNative Hawaiian or Other Pacific IslanderPolymorphism, Single NucleotideRacial GroupsTaiwanConceptsProportion of chromosomesAlcohol dehydrogenase geneDehydrogenase geneChromosome 4Functional variantsChromosomesLinkage disequilibriumADH2Functional polymorphismsADH3Allele frequenciesPairwise disequilibriumGenesIntronic polymorphismDisequilibriumPolymorphismDifferent efficienciesRisk of alcoholismHigher VmaxClass I alcohol dehydrogenase (ADH) genesVariantsLociKbHaplotypesPopulation
1994
Detection of DNA sequence variation via deliberate heteroduplex formation from genomic DNAs amplified en masse in "population tubes".
Ruano G, Deinard A, Tishkoff S, Kidd K. Detection of DNA sequence variation via deliberate heteroduplex formation from genomic DNAs amplified en masse in "population tubes". Genome Research 1994, 3: 225-231. PMID: 8173512, DOI: 10.1101/gr.3.4.225.Peer-Reviewed Original ResearchConceptsDNA sequence variationSequence variationGenomic DNAGlucose-6-phosphate dehydrogenase geneX chromosome lociWide geographic distributionLarge-scale samplingLong intronsDehydrogenase geneAllelic variationHeteroduplex moleculesGeographic distributionAllelic variantsHeteroduplex formationChimpanzee samplesHuman populationGradient electrophoresisRare variantsDNAGradient gelsHeteroduplexesElectrophoresisIntronsGenesLoci
1990
The locus for the medium-chain acyl-CoA dehydrogenase gene on chromosome 1 is highly polymorphic
Kidd J, Matsubara Y, Castiglione C, Tanaka K, Kidd K. The locus for the medium-chain acyl-CoA dehydrogenase gene on chromosome 1 is highly polymorphic. Genomics 1990, 6: 89-93. PMID: 1968047, DOI: 10.1016/0888-7543(90)90451-y.Peer-Reviewed Original ResearchConceptsRestriction fragment length polymorphismMedium-chain acyl-CoA dehydrogenase (MCAD) geneAcyl-CoA dehydrogenase geneSomatic cell studiesMedium-chain acyl-CoA dehydrogenaseSignificant linkage disequilibriumAcyl-CoA dehydrogenaseLinkage mappingDehydrogenase geneRegional assignmentChromosome 1Fragment length polymorphismGenetic studiesLinkage analysisLinkage disequilibriumSitu hybridizationLength polymorphismLinkage studiesPGM1Clinical genetic studiesACADMGenesLociCell localizationRFLP systems