2004
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang E, Ding Y, Flodman P, Kidd J, Kidd K, Grady D, Ryder O, Spence M, Swanson J, Moyzis R. The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus. American Journal Of Human Genetics 2004, 74: 931-944. PMID: 15077199, PMCID: PMC1181986, DOI: 10.1086/420854.Peer-Reviewed Original ResearchConceptsLittle linkage disequilibriumHuman dopamine receptor D4 genePolymorphic sitesDNA sequence organizationMost polymorphic sitesPatterns of recombinationObserved LD patternRare mutational eventsDRD4 locusGenetic architectureHaplotype diversityPositive selectionMore polymorphismsSequence organizationGene locusTandem repeatsMutational eventsLD patternsLinkage disequilibriumDopamine receptor D4 geneLociPhysiological differencesSame alleleReceptor variantsAlleles
1993
Alleles at the dopamine D4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred
Barr C, Kennedy J, Lichter J, Van Tol H, Wetterberg L, Livak K, Kidd K. Alleles at the dopamine D4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred. American Journal Of Medical Genetics 1993, 48: 218-222. PMID: 8135305, DOI: 10.1002/ajmg.1320480409.Peer-Reviewed Original ResearchConceptsChromosome 11p15.5Receptor geneImperfect direct repeatsDopamine D4 receptor locusD4 receptor geneTyrosine hydroxylase locusDopamine D4 receptor geneSingle haplotypeFirst intronSequence variationCandidate genesG nucleotidesDirect repeatsReceptor locusGenetic markersThird exonLinkage analysisPolymorphic markersGenetic susceptibilityGenesLociClose linkageDRD4 locusAllelesRepeats