1996
Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia, type IIA: Implications for therapy
Gill J, Reyes-Múgica M, Iyengar S, Kidd K, Touloukian R, Smith C, Keller M, Genel M. Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia, type IIA: Implications for therapy. The Journal Of Pediatrics 1996, 129: 459-464. PMID: 8804341, DOI: 10.1016/s0022-3476(96)70084-7.Peer-Reviewed Original ResearchConceptsMedullary thyroid carcinomaMultiple endocrine neoplasiaEndocrine neoplasiaThyroid carcinomaMultifocal medullary thyroid carcinomaMetastatic medullary carcinomaElevated calcitonin levelsC-cell hyperplasiaType IIaAge 1 yearYears of ageYears 8 monthsYears 11 monthsIIA patientsLymph nodesCalcitonin levelsProphylactic thyroidectomyMedullary carcinomaStimulation testEarly presentationPositive findingsCarcinomaThyroidectomyNeoplasiaAge
1986
Understanding the Clinical Heterogeneity of Major Depression Using Family Data
Weissman M, Merikangas K, Priya W, Kidd K, Prusoff B, Leckman J, Pauls D. Understanding the Clinical Heterogeneity of Major Depression Using Family Data. JAMA Psychiatry 1986, 43: 430-434. PMID: 3964021, DOI: 10.1001/archpsyc.1986.01800050028003.Peer-Reviewed Original ResearchConceptsMajor depressionSymptom patternsHistory of hospitalizationClinical presentationClinical severityRecurrent depressionSecondary alcoholismClinical heterogeneitySuicidal ideationAnxiety disordersDepressionFamilial aggregationEarly ageDisordersCombination of criteriaAgeSubgroupsRiskOnsetPutative subgroupsHospitalization
1984
Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity
Weissman M, Wickramaratne P, Merikangas K, Leckman J, Prusoff B, Caruso K, Kidd K, Gammon G. Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity. JAMA Psychiatry 1984, 41: 1136-1143. PMID: 6508504, DOI: 10.1001/archpsyc.1984.01790230022003.Peer-Reviewed Original ResearchConceptsAge of onsetMajor depressionNormal control subjectsRelatives of probandsFamilial loadingControl subjectsEarly-onset depressionFirst-degree relativesYears of ageHigh familial loadingHigh riskNormal subjectsSpecificity of transmissionEarly adulthoodDepressionProbandsAgeMore studiesFamily studiesYoung personOnsetLater ageHomogeneous disorderSubjectsInverse relationship