2024
A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials.
Tong G, Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Pereira Macedo J, Meng C, Wang X, Caille A, Li F, Taljaard M. A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials. Clinical Trials 2024, 17407745241276137. PMID: 39377196, DOI: 10.1177/17407745241276137.Peer-Reviewed Original ResearchSmall-sample correctionsStepped-wedge cluster randomized trialCluster randomized trialSample size calculation methodGeneralized linear mixed modelsLongitudinal correlation structureSize calculation methodLinear mixed modelsPermutation testSample sizeBayesian approachRandomized trialsCorrelation structureMixed modelsBayesian analysisGeneralized estimating equationsPermutationMedian sample sizeIntervention conditionRandomization methodEquationsNational Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults
Wang Y, Leo-Summers L, Vander Wyk B, Davis-Plourde K, Gill T, Becher R. National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults. JAMA Network Open 2024, 7: e240028. PMID: 38416499, PMCID: PMC10902728, DOI: 10.1001/jamanetworkopen.2024.0028.Peer-Reviewed Original ResearchConceptsCenters for Medicare & Medicaid ServicesFee-for-serviceMedicare Advantage beneficiariesHospital readmissionUS residentsNational Health and Aging Trends Study dataCommunity-living older adultsProspective longitudinal cohort studyCommunity-living participantsRate of hospital readmissionLikelihood of hospital readmissionPopulation-based estimatesNationally representative estimatesSex-adjusted modelsCommunity-livingData linkageGeriatric conditionsMedicaid ServicesOlder personsOlder adultsMain OutcomesNational estimatesRepresentative estimatesData analysisCohort study
2023
Adherence to key recommendations for design and analysis of stepped-wedge cluster randomized trials: A review of trials published 2016–2022
Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Macedo J, Meng C, Tong G, Wang X, Ortiz-Reyes L, Caille A, Li F, Taljaard M. Adherence to key recommendations for design and analysis of stepped-wedge cluster randomized trials: A review of trials published 2016–2022. Clinical Trials 2023, 21: 199-210. PMID: 37990575, PMCID: PMC11003836, DOI: 10.1177/17407745231208397.Peer-Reviewed Original ResearchAssessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US
Festa N, Throgmorton K, Davis-Plourde K, Dosa D, Chen K, Zang E, Kelly J, Gill T. Assessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US. JAMA Network Open 2023, 6: e2320207. PMID: 37358851, PMCID: PMC10293909, DOI: 10.1001/jamanetworkopen.2023.20207.Peer-Reviewed Original ResearchConceptsCross-sectional studyNursing homesNursing home characteristicsMean survival timeUS nursing homesGreater mean numberPrimary outcomeUS CentersExposure statusMAIN OUTCOMEElevated riskSurvival timeSurvival analysisPresence of deficienciesMore deficienciesRisk statusEmergency preparednessHome characteristicsMean numberRiskPreparedness standardsDeficiencyResponsivenessHigh percentageOutcomesA scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials
Nevins P, Davis-Plourde K, Pereira Macedo J, Ouyang Y, Ryan M, Tong G, Wang X, Meng C, Ortiz-Reyes L, Li F, Caille A, Taljaard M. A scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials. Journal Of Clinical Epidemiology 2023, 157: 134-145. PMID: 36931478, PMCID: PMC10546924, DOI: 10.1016/j.jclinepi.2023.03.010.Peer-Reviewed Original ResearchConceptsStepped-wedge clusterIndividual-level characteristicsMethod of randomizationCross-sectional designControl armBaseline imbalancesCohort designMedian numberElectronic searchPrimary analysisBaseline balanceStudy designPrimary reportsBaselineTrialsIntervention conditionSW-CRTsRandomizationReporting
2022
Power analyses for stepped wedge designs with multivariate continuous outcomes
Davis‐Plourde K, Taljaard M, Li F. Power analyses for stepped wedge designs with multivariate continuous outcomes. Statistics In Medicine 2022, 42: 559-578. PMID: 36565050, PMCID: PMC9985483, DOI: 10.1002/sim.9632.Peer-Reviewed Original ResearchConceptsMultivariate outcomesMultivariate linear mixed modelIntracluster correlation coefficientSample size proceduresClosed cohort designRigorous justificationSample size calculation procedureTreatment effect estimatorJoint distributionSize proceduresTest statisticLinear mixed modelsEfficient treatment effect estimatorsCommon treatment effectMixed modelsCalculation procedureExtensive simulationsEffects estimatorIntersection-union testPower analysisEstimatorWedge designEfficient powerModelContinuous outcomesNon-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study
Weinstein G, O’Donnell A, Davis-Plourde K, Zelber-Sagi S, Ghosh S, DeCarli CS, Thibault EG, Sperling RA, Johnson KA, Beiser AS, Seshadri S. Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study. Journal Of Alzheimer's Disease 2022, 86: 1371-1383. PMID: 35213373, PMCID: PMC11323287, DOI: 10.3233/jad-215409.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseasePrevalent non-alcoholic fatty liver diseaseFIB-4 indexFatty liver diseaseAlzheimer's disease pathologyFIB-4Liver fibrosisDisease pathologyAdvanced fibrosisLiver diseaseTau pathologyRisk factorsRelationship of NAFLDTau positron emission tomography (PET) imagingEarly Alzheimer's disease pathologyCardio-metabolic risk factorsAlcoholic fatty liver diseaseThird Generation cohortsFramingham Study participantsNon-invasive indexPositron emission tomography (PET) imagingEmission Tomography ImagingMiddle-aged adultsRegional tauLiver steatosisJoint Models for Estimating Determinants of Cognitive Decline in the Presence of Survival Bias
Davis-Plourde KL, Mayeda ER, Lodi S, Filshtein T, Beiser A, Gross AL, Seshadri S, Glymour MM, Tripodis Y. Joint Models for Estimating Determinants of Cognitive Decline in the Presence of Survival Bias. Epidemiology 2022, 33: 362-371. PMID: 35383644, DOI: 10.1097/ede.0000000000001472.Peer-Reviewed Original ResearchConceptsCognitive declineSurvival biasCox proportional hazards modelHazard of mortalityProportional hazards modelExposure of interestEffect of educationEffects of exposureHazards modelDementia diagnosisAlzheimer's diseaseMixed-effects modelsGEE modelMortalitySurvivalInconsistent resultsDiseaseInformative attritionStudy dataAttrition weightsExposure
2021
Sample Size Considerations for Stepped Wedge Designs with Subclusters
Davis-Plourde K, Taljaard M, Li F. Sample Size Considerations for Stepped Wedge Designs with Subclusters. Biometrics 2021, 79: 98-112. PMID: 34719017, PMCID: PMC9054939, DOI: 10.1111/biom.13596.Peer-Reviewed Original ResearchCoronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study
Suzuki H, Davis-Plourde K, Beiser A, Kunimura A, Miura K, DeCarli C, Maillard P, Mitchell GF, Vasan RS, Seshadri S, Fujiyoshi A. Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study. Circulation Cardiovascular Imaging 2021, 14: e011753. PMID: 34256573, PMCID: PMC8323993, DOI: 10.1161/circimaging.120.011753.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAsymptomatic DiseasesCoronary AngiographyCoronary Artery DiseaseDiffusion Tensor ImagingFemaleHumansLeukoencephalopathiesMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSex FactorsTime FactorsVascular CalcificationConceptsCoronary artery calciumWhite matter injurySubtle white matter injuryAsymptomatic middle-aged menCAC scoreMiddle-aged menFractional anisotropyCAC groupDiffusion tensor imaging-based measuresCarotid-femoral pulse wave velocityLog-transformed CAC scoreSecondary analysisBrain magnetic resonance imagingPredictors of strokePulse wave velocityCross-sectional associationsMagnetic resonance diffusion tensorImaging-based measuresMagnetic resonance imagingLower fractional anisotropyFramingham Heart StudyMiddle-age adultsArtery calciumMultivariable adjustmentAortic stiffnessAutonomic Imbalance and Risk of Dementia and Stroke
Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke. Stroke 2021, 52: 2068-2076. PMID: 33874747, PMCID: PMC8154675, DOI: 10.1161/strokeaha.120.030601.Peer-Reviewed Original ResearchConceptsHeart rate variabilityAutonomic imbalanceHeart rateDementia riskRate variabilityStroke riskNormal intervalsCardiac autonomic imbalanceLower heart rate variabilityLower stroke riskCommunity-based cohortRisk of dementiaSuccessive differencesAutonomic nervous systemNormal RR intervalsOlder-aged adultsExam 7Incident strokeDementia pathophysiologyIncident dementiaPotential confoundersStroke occurrenceDementia incidenceThird examinationNervous systemAortic stiffness and cerebral microbleeds: The Framingham Heart Study
Romero JR, Himali JJ, Beiser A, Pase MP, Davis-Plourde KL, Parva P, Seshadri S, Mitchell GF. Aortic stiffness and cerebral microbleeds: The Framingham Heart Study. Vascular Medicine 2021, 26: 312-314. PMID: 33393444, DOI: 10.1177/1358863x20979740.Peer-Reviewed Original Research
2020
Pathways to housing stability and viral suppression for people living with HIV/AIDS: Findings from the Building a Medical Home for Multiply Diagnosed HIV-positive Homeless Populations initiative
Rajabiun S, Davis-Plourde K, Tinsley M, Quinn EK, Borne D, Maskay MH, Giordano TP, Cabral HJ. Pathways to housing stability and viral suppression for people living with HIV/AIDS: Findings from the Building a Medical Home for Multiply Diagnosed HIV-positive Homeless Populations initiative. PLOS ONE 2020, 15: e0239190. PMID: 33001986, PMCID: PMC7529314, DOI: 10.1371/journal.pone.0239190.Peer-Reviewed Original ResearchConceptsHIV health outcomesViral suppressionHealth outcomesMedical homeOpiate useLower riskHIV primary medical careServices Administration's Special ProjectsCo-occurring substance useHIV primary careStandardized encounter formsHIV/AIDS service organizationsHousing stabilityMedical chart reviewQualified health centersPrimary medical careMental health diagnosesCounty Health DepartmentStable housingDirect effectAIDS service organizationsHIV/AIDSNon-medical servicesNavigation interventionChart review27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium
Wolters FJ, Chibnik LB, Waziry R, Anderson R, Berr C, Beiser A, Bis JC, Blacker D, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Davis-Plourde KL, de Wolf F, Debette S, Dufouil C, Fornage M, Goudsmit J, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikram MA, Ikram MK, Joas E, Kern S, Kuller LH, Launer L, Lopez OL, Matthews FE, McRae-McKee K, Meirelles O, Mosley TH, Pase MP, Psaty BM, Satizabal CL, Seshadri S, Skoog I, Stephan BCM, Wetterberg H, Wong MM, Zettergren A, Hofman A. 27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium. Neurology 2020, 95: 10.1212/wnl.0000000000010022. PMID: 32611641, PMCID: PMC7455342, DOI: 10.1212/wnl.0000000000010022.Peer-Reviewed Original ResearchAssociation of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia
Lee CM, Woodward M, Batty GD, Beiser AS, Bell S, Berr C, Bjertness E, Chalmers J, Clarke R, Dartigues J, Davis‐Plourde K, Debette S, Di Angelantonio E, Feart C, Frikke‐Schmidt R, Gregson J, Haan MN, Hassing LB, Hayden KM, Hoevenaar‐Blom M, Kaprio J, Kivimaki M, Lappas G, Larson EB, LeBlanc ES, Lee A, Lui L, van Charante E, Ninomiya T, Nordestgaard L, Ohara T, Ohkuma T, Palviainen T, Peres K, Peters R, Qizilbash N, Richard E, Rosengren A, Seshadri S, Shipley M, Singh‐Manoux A, Strand BH, van Gool W, Vuoksimaa E, Yaffe K, Huxley RR. Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia. Obesity Reviews 2020, 21: e12989. PMID: 31898862, PMCID: PMC7079047, DOI: 10.1111/obr.12989.Peer-Reviewed Original ResearchConceptsVascular dementia riskRisk of dementiaDementia riskWaist circumferenceWeight changeWeight lossLow-normal weightProspective cohort studyUpper normal levelBody mass indexAssociation of anthropometryCases of dementiaPercent weight changeCause dementia riskGlobal obesity epidemicNon-linear associationCohort studyCause dementiaVascular dementiaMass indexWeight maintenanceDementia subtypesPathophysiological changesClinical trialsUnderweight individuals
2019
Author response: Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham study
Weinstein G, Davis‐Plourde K, Beiser AS, Seshadri S. Author response: Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham study. Liver International 2019, 40: 1240-1240. PMID: 31850659, DOI: 10.1111/liv.14318.Peer-Reviewed Original ResearchAntihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies
Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guðnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. The Lancet Neurology 2019, 19: 61-70. PMID: 31706889, PMCID: PMC7391421, DOI: 10.1016/s1474-4422(19)30393-x.Peer-Reviewed Original ResearchConceptsBlood pressure strataAntihypertensive medicationsBlood pressureRisk of dementiaIndividual participant dataIncident dementiaAlzheimer's diseaseDementia eventsDrug classesAging Intramural Research ProgramHigh blood pressure strataProspective community-based studyStudy-specific effect estimatesParticipant dataSpecific antihypertensive medicationsAlzheimer's Drug Discovery FoundationNormal blood pressureProspective cohort studyEligible observational studiesHigh blood pressureClinical Alzheimer's diseaseBurden of diseaseCommunity-based studyFuture clinical guidelinesCommunity-dwelling adultsP4‐543: AUTONOMIC BALANCE INDICES AND RISK OF DEMENTIA: THE FRAMINGHAM STUDY
Weinstein G, Davis-Plourde K, Beiser A, Seshadri S. P4‐543: AUTONOMIC BALANCE INDICES AND RISK OF DEMENTIA: THE FRAMINGHAM STUDY. Alzheimer's & Dementia 2019, 15: p1524-p1524. DOI: 10.1016/j.jalz.2019.08.090.Peer-Reviewed Original ResearchP2‐562: NON‐ALCOHOLIC FATTY LIVER DISEASE, LIVER FIBROSIS SCORE AND COGNITIVE FUNCTION IN MIDDLE‐AGED ADULTS: THE FRAMINGHAM STUDY
Weinstein G, Davis-Plourde K, Himali J, Zelber-Sagi S, Beiser A, Seshadri S. P2‐562: NON‐ALCOHOLIC FATTY LIVER DISEASE, LIVER FIBROSIS SCORE AND COGNITIVE FUNCTION IN MIDDLE‐AGED ADULTS: THE FRAMINGHAM STUDY. Alzheimer's & Dementia 2019, 15: p837-p838. DOI: 10.1016/j.jalz.2019.06.2971.Peer-Reviewed Original ResearchNon‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham Study
Weinstein G, Davis‐Plourde K, Himali JJ, Zelber‐Sagi S, Beiser AS, Seshadri S. Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham Study. Liver International 2019, 39: 1713-1721. PMID: 31155826, PMCID: PMC6736704, DOI: 10.1111/liv.14161.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseNAFLD fibrosis scoreFatty liver diseaseCognitive functionAdvanced fibrosisFibrosis scoreLiver diseaseBrain healthLower riskPresence of NAFLDRelationship of NAFLDLiver fibrosis scoresExcessive alcohol intakeVisceral adipose tissueSeverity of fibrosisPoor cognitive functionMiddle-aged adultsExecutive functionCross-sectional relationshipNAFLD diagnosisCardiometabolic variablesAlcohol intakeFramingham StudyInsulin resistancePotential confounders