2024
National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults
Wang Y, Leo-Summers L, Vander Wyk B, Davis-Plourde K, Gill T, Becher R. National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults. JAMA Network Open 2024, 7: e240028. PMID: 38416499, PMCID: PMC10902728, DOI: 10.1001/jamanetworkopen.2024.0028.Peer-Reviewed Original ResearchConceptsCenters for Medicare & Medicaid ServicesFee-for-serviceMedicare Advantage beneficiariesHospital readmissionUS residentsNational Health and Aging Trends Study dataCommunity-living older adultsProspective longitudinal cohort studyCommunity-living participantsRate of hospital readmissionLikelihood of hospital readmissionPopulation-based estimatesNationally representative estimatesSex-adjusted modelsCommunity-livingData linkageGeriatric conditionsMedicaid ServicesOlder personsOlder adultsMain OutcomesNational estimatesRepresentative estimatesData analysisCohort study
2020
27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium
Wolters FJ, Chibnik LB, Waziry R, Anderson R, Berr C, Beiser A, Bis JC, Blacker D, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Davis-Plourde KL, de Wolf F, Debette S, Dufouil C, Fornage M, Goudsmit J, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikram MA, Ikram MK, Joas E, Kern S, Kuller LH, Launer L, Lopez OL, Matthews FE, McRae-McKee K, Meirelles O, Mosley TH, Pase MP, Psaty BM, Satizabal CL, Seshadri S, Skoog I, Stephan BCM, Wetterberg H, Wong MM, Zettergren A, Hofman A. 27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium. Neurology 2020, 95: 10.1212/wnl.0000000000010022. PMID: 32611641, PMCID: PMC7455342, DOI: 10.1212/wnl.0000000000010022.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overCohort StudiesDementiaEuropeFemaleHumansIncidenceMaleSex DistributionUnited States
2019
Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies
Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guðnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. The Lancet Neurology 2019, 19: 61-70. PMID: 31706889, PMCID: PMC7391421, DOI: 10.1016/s1474-4422(19)30393-x.Peer-Reviewed Original ResearchConceptsBlood pressure strataAntihypertensive medicationsBlood pressureRisk of dementiaIndividual participant dataIncident dementiaAlzheimer's diseaseDementia eventsDrug classesAging Intramural Research ProgramHigh blood pressure strataProspective community-based studyStudy-specific effect estimatesParticipant dataSpecific antihypertensive medicationsAlzheimer's Drug Discovery FoundationNormal blood pressureProspective cohort studyEligible observational studiesHigh blood pressureClinical Alzheimer's diseaseBurden of diseaseCommunity-based studyFuture clinical guidelinesCommunity-dwelling adults
2018
Vascular risk at younger ages most strongly associates with current and future brain volume.
Pase MP, Davis-Plourde K, Himali JJ, Satizabal CL, Aparicio H, Seshadri S, Beiser AS, DeCarli C. Vascular risk at younger ages most strongly associates with current and future brain volume. Neurology 2018, 91: e1479-e1486. PMID: 30232248, PMCID: PMC6202941, DOI: 10.1212/wnl.0000000000006360.Peer-Reviewed Original ResearchConceptsVascular risk factor burdenRisk factor burdenVascular risk factorsLower brain volumeRisk factorsStrength of associationBrain volumeYounger ageAge decadeFramingham Stroke Risk ProfileAge 45 yearsPotential therapeutic effectsStroke Risk ProfileLongitudinal analysisFramingham Heart StudyCross-sectional analysisStroke riskVascular riskDementia riskAge 45Therapeutic effectHeart StudyRisk profileBrain structuresCross-sectional data
2017
Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium
Chibnik LB, Wolters FJ, Bäckman K, Beiser A, Berr C, Bis JC, Boerwinkle E, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Debette S, Davis-Plourde KL, Dufouil C, Fornage M, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikram MA, Ikram MK, Kern S, Kuller LH, Launer L, Lopez OL, Matthews F, Meirelles O, Mosley T, Ower A, Psaty BM, Satizabal CL, Seshadri S, Skoog I, Stephan BCM, Tzourio C, Waziry R, Wong MM, Zettergren A, Hofman A. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. European Journal Of Epidemiology 2017, 32: 931-938. PMID: 29063414, PMCID: PMC5680377, DOI: 10.1007/s10654-017-0320-5.Peer-Reviewed Original ResearchConceptsIncidence of dementiaCox proportional hazards regressionPopulation-based cohortProportional hazards regressionRisk of dementiaBurden of diseaseInternational population-based cohortsRange of followPoisson regression modelsHazards regressionDementia occurrenceIncidence rateAPOE genotypeAverage ageCohortPreventive effortsDementiaUnderlying causeIncidenceCumulative hazardImpact of genderRegression modelsFollowAtrial fibrillation and cognitive decline in the Framingham Heart Study
Nishtala A, Piers RJ, Himali JJ, Beiser AS, Davis-Plourde KL, Saczynski JS, McManus DD, Benjamin EJ, Au R. Atrial fibrillation and cognitive decline in the Framingham Heart Study. Heart Rhythm 2017, 15: 166-172. PMID: 28943482, PMCID: PMC5881912, DOI: 10.1016/j.hrthm.2017.09.036.Peer-Reviewed Original ResearchConceptsPrevalent atrial fibrillationVascular risk factorsAtrial fibrillationFramingham Heart StudyAF statusRisk factorsAPOE4 statusHeart StudyOffspring CohortVascular risk factor burdenCognitive performanceNP assessmentExecutive functionLongitudinal declineRisk factor burdenDomain-specific cognitive performanceApolipoprotein ε4 statusBaseline neuropsychological assessmentCross-sectional analysisInter-test intervalEligible participantsOriginal cohortVascular profilesΕ4 statusCognitive declineOverweight, Obesity, and Survival After Stroke in the Framingham Heart Study
Aparicio HJ, Himali JJ, Beiser AS, Davis‐Plourde K, Vasan RS, Kase CS, Wolf PA, Seshadri S. Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study. Journal Of The American Heart Association 2017, 6: e004721. PMID: 28647687, PMCID: PMC5669145, DOI: 10.1161/jaha.116.004721.Peer-Reviewed Original ResearchConceptsIschemic strokeNormal weightStroke casesBody weightBody mass index measurementsWeight lossStable normal weightUnknown protective factorsStroke-free controlsNormal-weight participantsIschemic stroke casesCommunity-based sampleCase-control designFramingham Heart StudyCause mortalityBMI 18.5BMI categoriesHemorrhagic strokeObese participantsOverweight participantsBMI measurementsHeart StudyLower mortalityCase statusStroke