2021
Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study
Suzuki H, Davis-Plourde K, Beiser A, Kunimura A, Miura K, DeCarli C, Maillard P, Mitchell GF, Vasan RS, Seshadri S, Fujiyoshi A. Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study. Circulation Cardiovascular Imaging 2021, 14: e011753. PMID: 34256573, PMCID: PMC8323993, DOI: 10.1161/circimaging.120.011753.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAsymptomatic DiseasesCoronary AngiographyCoronary Artery DiseaseDiffusion Tensor ImagingFemaleHumansLeukoencephalopathiesMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSex FactorsTime FactorsVascular CalcificationConceptsCoronary artery calciumWhite matter injurySubtle white matter injuryAsymptomatic middle-aged menCAC scoreMiddle-aged menFractional anisotropyCAC groupDiffusion tensor imaging-based measuresCarotid-femoral pulse wave velocityLog-transformed CAC scoreSecondary analysisBrain magnetic resonance imagingPredictors of strokePulse wave velocityCross-sectional associationsMagnetic resonance diffusion tensorImaging-based measuresMagnetic resonance imagingLower fractional anisotropyFramingham Heart StudyMiddle-age adultsArtery calciumMultivariable adjustmentAortic stiffness
2017
Atrial fibrillation and cognitive decline in the Framingham Heart Study
Nishtala A, Piers RJ, Himali JJ, Beiser AS, Davis-Plourde KL, Saczynski JS, McManus DD, Benjamin EJ, Au R. Atrial fibrillation and cognitive decline in the Framingham Heart Study. Heart Rhythm 2017, 15: 166-172. PMID: 28943482, PMCID: PMC5881912, DOI: 10.1016/j.hrthm.2017.09.036.Peer-Reviewed Original ResearchConceptsPrevalent atrial fibrillationVascular risk factorsAtrial fibrillationFramingham Heart StudyAF statusRisk factorsAPOE4 statusHeart StudyOffspring CohortVascular risk factor burdenCognitive performanceNP assessmentExecutive functionLongitudinal declineRisk factor burdenDomain-specific cognitive performanceApolipoprotein ε4 statusBaseline neuropsychological assessmentCross-sectional analysisInter-test intervalEligible participantsOriginal cohortVascular profilesΕ4 statusCognitive decline