2021
Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study
Suzuki H, Davis-Plourde K, Beiser A, Kunimura A, Miura K, DeCarli C, Maillard P, Mitchell GF, Vasan RS, Seshadri S, Fujiyoshi A. Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study. Circulation Cardiovascular Imaging 2021, 14: e011753. PMID: 34256573, PMCID: PMC8323993, DOI: 10.1161/circimaging.120.011753.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAsymptomatic DiseasesCoronary AngiographyCoronary Artery DiseaseDiffusion Tensor ImagingFemaleHumansLeukoencephalopathiesMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSex FactorsTime FactorsVascular CalcificationConceptsCoronary artery calciumWhite matter injurySubtle white matter injuryAsymptomatic middle-aged menCAC scoreMiddle-aged menFractional anisotropyCAC groupDiffusion tensor imaging-based measuresCarotid-femoral pulse wave velocityLog-transformed CAC scoreSecondary analysisBrain magnetic resonance imagingPredictors of strokePulse wave velocityCross-sectional associationsMagnetic resonance diffusion tensorImaging-based measuresMagnetic resonance imagingLower fractional anisotropyFramingham Heart StudyMiddle-age adultsArtery calciumMultivariable adjustmentAortic stiffness
2020
Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia
Lee CM, Woodward M, Batty GD, Beiser AS, Bell S, Berr C, Bjertness E, Chalmers J, Clarke R, Dartigues J, Davis‐Plourde K, Debette S, Di Angelantonio E, Feart C, Frikke‐Schmidt R, Gregson J, Haan MN, Hassing LB, Hayden KM, Hoevenaar‐Blom M, Kaprio J, Kivimaki M, Lappas G, Larson EB, LeBlanc ES, Lee A, Lui L, van Charante E, Ninomiya T, Nordestgaard L, Ohara T, Ohkuma T, Palviainen T, Peres K, Peters R, Qizilbash N, Richard E, Rosengren A, Seshadri S, Shipley M, Singh‐Manoux A, Strand BH, van Gool W, Vuoksimaa E, Yaffe K, Huxley RR. Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia. Obesity Reviews 2020, 21: e12989. PMID: 31898862, PMCID: PMC7079047, DOI: 10.1111/obr.12989.Peer-Reviewed Original ResearchConceptsVascular dementia riskRisk of dementiaDementia riskWaist circumferenceWeight changeWeight lossLow-normal weightProspective cohort studyUpper normal levelBody mass indexAssociation of anthropometryCases of dementiaPercent weight changeCause dementia riskGlobal obesity epidemicNon-linear associationCohort studyCause dementiaVascular dementiaMass indexWeight maintenanceDementia subtypesPathophysiological changesClinical trialsUnderweight individuals
2019
Author response: Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham study
Weinstein G, Davis‐Plourde K, Beiser AS, Seshadri S. Author response: Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham study. Liver International 2019, 40: 1240-1240. PMID: 31850659, DOI: 10.1111/liv.14318.Peer-Reviewed Original ResearchNon‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham Study
Weinstein G, Davis‐Plourde K, Himali JJ, Zelber‐Sagi S, Beiser AS, Seshadri S. Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham Study. Liver International 2019, 39: 1713-1721. PMID: 31155826, PMCID: PMC6736704, DOI: 10.1111/liv.14161.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseNAFLD fibrosis scoreFatty liver diseaseCognitive functionAdvanced fibrosisFibrosis scoreLiver diseaseBrain healthLower riskPresence of NAFLDRelationship of NAFLDLiver fibrosis scoresExcessive alcohol intakeVisceral adipose tissueSeverity of fibrosisPoor cognitive functionMiddle-aged adultsExecutive functionCross-sectional relationshipNAFLD diagnosisCardiometabolic variablesAlcohol intakeFramingham StudyInsulin resistancePotential confoundersAssociation of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts
Weinstein G, Davis-Plourde KL, Conner S, Himali JJ, Beiser AS, Lee A, Rawlings AM, Sedaghat S, Ding J, Moshier E, van Duijn CM, Beeri MS, Selvin E, Ikram MA, Launer LJ, Haan MN, Seshadri S. Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts. PLOS ONE 2019, 14: e0212293. PMID: 30768625, PMCID: PMC6377188, DOI: 10.1371/journal.pone.0212293.Peer-Reviewed Original ResearchConceptsInsulin useMRI measuresDementia/AD riskCognitive functionAssociation of metforminGlycemic control propertiesNew-onset dementiaSacramento Area Latino StudyCox regression analysisBrain MRI measuresPopulation-based cohortRisk of dementiaAdverse cognitive outcomesLife style changesGlobal cognitive functionFramingham Heart StudySulfonylurea useDiabetes medicationsReykjavik StudyGlycemic dysregulationRenal functionGlycemic controlRotterdam StudyDementia riskIncident dementia
2018
APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality
Satizabal CL, Samieri C, Davis-Plourde KL, Voetsch B, Aparicio HJ, Pase MP, Romero JR, Helmer C, Vasan RS, Kase CS, Debette S, Beiser AS, Seshadri S. APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality. Stroke 2018, 49: 2822-2829. PMID: 30571417, PMCID: PMC6310220, DOI: 10.1161/strokeaha.118.022132.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseAPOE ε4 carriersRisk of strokeHeart diseaseSD unit increaseCause strokeIschemic strokeCause mortality eventsPlasma fatty acidsFatty acidsAPOE ε4 genotypeRandom-effects modelFatty acid levelsUnit increaseMeta-analysis resultsMetabolism of lipidsLinoleic acidCause mortalityMean agePotential confoundersCardiovascular healthRisk factorsAPOE genotypeCardiovascular diseaseDietary fatVascular risk at younger ages most strongly associates with current and future brain volume.
Pase MP, Davis-Plourde K, Himali JJ, Satizabal CL, Aparicio H, Seshadri S, Beiser AS, DeCarli C. Vascular risk at younger ages most strongly associates with current and future brain volume. Neurology 2018, 91: e1479-e1486. PMID: 30232248, PMCID: PMC6202941, DOI: 10.1212/wnl.0000000000006360.Peer-Reviewed Original ResearchConceptsVascular risk factor burdenRisk factor burdenVascular risk factorsLower brain volumeRisk factorsStrength of associationBrain volumeYounger ageAge decadeFramingham Stroke Risk ProfileAge 45 yearsPotential therapeutic effectsStroke Risk ProfileLongitudinal analysisFramingham Heart StudyCross-sectional analysisStroke riskVascular riskDementia riskAge 45Therapeutic effectHeart StudyRisk profileBrain structuresCross-sectional data
2017
Atrial fibrillation and cognitive decline in the Framingham Heart Study
Nishtala A, Piers RJ, Himali JJ, Beiser AS, Davis-Plourde KL, Saczynski JS, McManus DD, Benjamin EJ, Au R. Atrial fibrillation and cognitive decline in the Framingham Heart Study. Heart Rhythm 2017, 15: 166-172. PMID: 28943482, PMCID: PMC5881912, DOI: 10.1016/j.hrthm.2017.09.036.Peer-Reviewed Original ResearchConceptsPrevalent atrial fibrillationVascular risk factorsAtrial fibrillationFramingham Heart StudyAF statusRisk factorsAPOE4 statusHeart StudyOffspring CohortVascular risk factor burdenCognitive performanceNP assessmentExecutive functionLongitudinal declineRisk factor burdenDomain-specific cognitive performanceApolipoprotein ε4 statusBaseline neuropsychological assessmentCross-sectional analysisInter-test intervalEligible participantsOriginal cohortVascular profilesΕ4 statusCognitive declineOverweight, Obesity, and Survival After Stroke in the Framingham Heart Study
Aparicio HJ, Himali JJ, Beiser AS, Davis‐Plourde K, Vasan RS, Kase CS, Wolf PA, Seshadri S. Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study. Journal Of The American Heart Association 2017, 6: e004721. PMID: 28647687, PMCID: PMC5669145, DOI: 10.1161/jaha.116.004721.Peer-Reviewed Original ResearchConceptsIschemic strokeNormal weightStroke casesBody weightBody mass index measurementsWeight lossStable normal weightUnknown protective factorsStroke-free controlsNormal-weight participantsIschemic stroke casesCommunity-based sampleCase-control designFramingham Heart StudyCause mortalityBMI 18.5BMI categoriesHemorrhagic strokeObese participantsOverweight participantsBMI measurementsHeart StudyLower mortalityCase statusStroke