2022
Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study
Weinstein G, O’Donnell A, Davis-Plourde K, Zelber-Sagi S, Ghosh S, DeCarli CS, Thibault EG, Sperling RA, Johnson KA, Beiser AS, Seshadri S. Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study. Journal Of Alzheimer's Disease 2022, 86: 1371-1383. PMID: 35213373, PMCID: PMC11323287, DOI: 10.3233/jad-215409.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseasePrevalent non-alcoholic fatty liver diseaseFIB-4 indexFatty liver diseaseAlzheimer's disease pathologyFIB-4Liver fibrosisDisease pathologyAdvanced fibrosisLiver diseaseTau pathologyRisk factorsRelationship of NAFLDTau positron emission tomography (PET) imagingEarly Alzheimer's disease pathologyCardio-metabolic risk factorsAlcoholic fatty liver diseaseThird Generation cohortsFramingham Study participantsNon-invasive indexPositron emission tomography (PET) imagingEmission Tomography ImagingMiddle-aged adultsRegional tauLiver steatosis
2019
Author response: Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham study
Weinstein G, Davis‐Plourde K, Beiser AS, Seshadri S. Author response: Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham study. Liver International 2019, 40: 1240-1240. PMID: 31850659, DOI: 10.1111/liv.14318.Peer-Reviewed Original ResearchP2‐562: NON‐ALCOHOLIC FATTY LIVER DISEASE, LIVER FIBROSIS SCORE AND COGNITIVE FUNCTION IN MIDDLE‐AGED ADULTS: THE FRAMINGHAM STUDY
Weinstein G, Davis-Plourde K, Himali J, Zelber-Sagi S, Beiser A, Seshadri S. P2‐562: NON‐ALCOHOLIC FATTY LIVER DISEASE, LIVER FIBROSIS SCORE AND COGNITIVE FUNCTION IN MIDDLE‐AGED ADULTS: THE FRAMINGHAM STUDY. Alzheimer's & Dementia 2019, 15: p837-p838. DOI: 10.1016/j.jalz.2019.06.2971.Peer-Reviewed Original ResearchNon‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham Study
Weinstein G, Davis‐Plourde K, Himali JJ, Zelber‐Sagi S, Beiser AS, Seshadri S. Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham Study. Liver International 2019, 39: 1713-1721. PMID: 31155826, PMCID: PMC6736704, DOI: 10.1111/liv.14161.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseNAFLD fibrosis scoreFatty liver diseaseCognitive functionAdvanced fibrosisFibrosis scoreLiver diseaseBrain healthLower riskPresence of NAFLDRelationship of NAFLDLiver fibrosis scoresExcessive alcohol intakeVisceral adipose tissueSeverity of fibrosisPoor cognitive functionMiddle-aged adultsExecutive functionCross-sectional relationshipNAFLD diagnosisCardiometabolic variablesAlcohol intakeFramingham StudyInsulin resistancePotential confoundersSelf‐Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study
Spartano NL, Davis-Plourde KL, Himali JJ, Murabito JM, Vasan RS, Beiser AS, Seshadri S. Self‐Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study. Journal Of Diabetes Research 2019, 2019: 2718465. PMID: 30729134, PMCID: PMC6343169, DOI: 10.1155/2019/2718465.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorIGF-1 levelsDiabetes mellitusAmbulatory physical activityPhysical activityIGF-1Neurotrophic factorBrain-derived neurotrophic factor levelsHigher IGF-1 levelsInsulin-like growth factor-1Self-reported physical activityExamination cycle 7Higher BDNF levelsNeurotrophic factor levelsHormone replacement therapyPrevalent cardiovascular diseaseTotal physical activityFramingham Offspring StudyGrowth factor-1Multivariable regression modelsPhysical activity variablesMore physical activityEndothelial growth factorMiddle-aged adultsLinear multivariable regression models