2024
A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials.
Tong G, Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Pereira Macedo J, Meng C, Wang X, Caille A, Li F, Taljaard M. A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials. Clinical Trials 2024, 17407745241276137. PMID: 39377196, DOI: 10.1177/17407745241276137.Peer-Reviewed Original ResearchSmall-sample correctionsStepped-wedge cluster randomized trialCluster randomized trialSample size calculation methodGeneralized linear mixed modelsLongitudinal correlation structureSize calculation methodLinear mixed modelsPermutation testSample sizeBayesian approachRandomized trialsCorrelation structureMixed modelsBayesian analysisGeneralized estimating equationsPermutationMedian sample sizeIntervention conditionRandomization methodEquations
2022
Power analyses for stepped wedge designs with multivariate continuous outcomes
Davis‐Plourde K, Taljaard M, Li F. Power analyses for stepped wedge designs with multivariate continuous outcomes. Statistics In Medicine 2022, 42: 559-578. PMID: 36565050, PMCID: PMC9985483, DOI: 10.1002/sim.9632.Peer-Reviewed Original ResearchConceptsMultivariate outcomesMultivariate linear mixed modelIntracluster correlation coefficientSample size proceduresClosed cohort designRigorous justificationSample size calculation procedureTreatment effect estimatorJoint distributionSize proceduresTest statisticLinear mixed modelsEfficient treatment effect estimatorsCommon treatment effectMixed modelsCalculation procedureExtensive simulationsEffects estimatorIntersection-union testPower analysisEstimatorWedge designEfficient powerModelContinuous outcomes