2022
Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study
Weinstein G, O’Donnell A, Davis-Plourde K, Zelber-Sagi S, Ghosh S, DeCarli CS, Thibault EG, Sperling RA, Johnson KA, Beiser AS, Seshadri S. Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-β and Tau Pathology in Middle-Aged Adults: The Framingham Study. Journal Of Alzheimer's Disease 2022, 86: 1371-1383. PMID: 35213373, PMCID: PMC11323287, DOI: 10.3233/jad-215409.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseasePrevalent non-alcoholic fatty liver diseaseFIB-4 indexFatty liver diseaseAlzheimer's disease pathologyFIB-4Liver fibrosisDisease pathologyAdvanced fibrosisLiver diseaseTau pathologyRisk factorsRelationship of NAFLDTau positron emission tomography (PET) imagingEarly Alzheimer's disease pathologyCardio-metabolic risk factorsAlcoholic fatty liver diseaseThird Generation cohortsFramingham Study participantsNon-invasive indexPositron emission tomography (PET) imagingEmission Tomography ImagingMiddle-aged adultsRegional tauLiver steatosis
2019
Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham Study
Weinstein G, Davis‐Plourde K, Himali JJ, Zelber‐Sagi S, Beiser AS, Seshadri S. Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham Study. Liver International 2019, 39: 1713-1721. PMID: 31155826, PMCID: PMC6736704, DOI: 10.1111/liv.14161.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseNAFLD fibrosis scoreFatty liver diseaseCognitive functionAdvanced fibrosisFibrosis scoreLiver diseaseBrain healthLower riskPresence of NAFLDRelationship of NAFLDLiver fibrosis scoresExcessive alcohol intakeVisceral adipose tissueSeverity of fibrosisPoor cognitive functionMiddle-aged adultsExecutive functionCross-sectional relationshipNAFLD diagnosisCardiometabolic variablesAlcohol intakeFramingham StudyInsulin resistancePotential confounders