A TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer
Wu VT, Kiriazov B, Koch KE, Gu VW, Beck AC, Borcherding N, Li T, Addo P, Wehrspan ZJ, Zhang W, Braun TA, Brown BJ, Band V, Band H, Kulak MV, Weigel RJ. A TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer. Molecular Cancer Research 2020, 18: 46-56. PMID: 31619506, PMCID: PMC6942205, DOI: 10.1158/1541-7786.mcr-19-0359.Peer-Reviewed Original ResearchConceptsBreast cancerGene signatureAP-2γHER2-positive breast cancerOutcomes of patientsExpression of estrogenSubset of patientsLuminal breast cancerSubset of HER2AP-2γ transcription factorBreast cancer subtypesPathway analysisPhysiologic effectsClinical relevanceCancer growthHER2Hormone responseCancer subtypesDifferent HER2CancerPatientsRetinoic acid pathwayCancer linesOutcomesCell lines