AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells
Gu VW, Cho E, Thompson DT, Cassady VC, Borcherding N, Koch KE, Wu VT, Lorenzen AW, van der Heide DM, White JR, Kulak MV, Williams T, Zhang W, Weigel RJ. AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells. Stem Cell Reports 2020, 16: 106-119. PMID: 33382976, PMCID: PMC7897584, DOI: 10.1016/j.stemcr.2020.12.002.Peer-Reviewed Original ResearchConceptsMammary stem cellsAP-2γMultipotent mammary stem cellsMammary gland ductal morphogenesisAP-2γ transcription factorMammary gland structureMammary gland developmentStem cellsMammary epithelial cellsAdult MaSCsBasal epitheliumDuctal outgrowthMammary developmentLuminal progenitorsConditional knockoutEpithelial cellsLuminal lineageMammary lineageDuctal morphogenesisGland developmentNumber of cellsRegenerative capacityGland structureExpression of genesCells