2021
A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response
Connolly KA, Kuchroo M, Venkat A, Khatun A, Wang J, William I, Hornick NI, Fitzgerald BL, Damo M, Kasmani MY, Cui C, Fagerberg E, Monroy I, Hutchins A, Cheung JF, Foster GG, Mariuzza DL, Nader M, Zhao H, Cui W, Krishnaswamy S, Joshi NS. A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response. Science Immunology 2021, 6: eabg7836. PMID: 34597124, PMCID: PMC8593910, DOI: 10.1126/sciimmunol.abg7836.Peer-Reviewed Original ResearchConceptsTumor-specific CD8T cellsTumor microenvironmentOngoing anti-tumor immune responseChronic lymphocytic choriomeningitis virus (LCMV) infectionTumor-draining lymph nodesAnti-tumor immune responseLymphocytic choriomeningitis virus infectionIntratumoral T cellsEfficacy of immunotherapyT cell responsesTumor-draining lymphAntitumor T cellsT cell terminal differentiationStem-like CD8Immunologic shiftGene expression signaturesLymph nodesTerminal differentiationLung tumorsVirus infectionLung adenocarcinomaImmune responseCD8Cell responses
2018
Investigating Tumor-Associated Tertiary Lymphoid Structures in Murine Lung Adenocarcinoma
Connolly KA, Nader M, Joshi N. Investigating Tumor-Associated Tertiary Lymphoid Structures in Murine Lung Adenocarcinoma. Methods In Molecular Biology 2018, 1845: 259-273. PMID: 30141018, DOI: 10.1007/978-1-4939-8709-2_15.ChaptersConceptsTertiary lymphoid structuresLung adenocarcinomaLymphoid structuresImmune cellsFluorescence-activated cell sortingLung lobesTumor-associated tertiary lymphoid structuresHuman lung cancer patientsStrong antitumor immune responseAdvanced stage diseaseAntitumor immune responseRegulatory T cellsLung cancer patientsMurine lung adenocarcinomaFunctional immune systemAnimal tumor modelsLymph nodesCancer patientsAutochthonous tumorsT cellsImmune responseMouse modelTherapeutic interventionsImmune systemTumor growth