2021
A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma
Fitzgerald B, Connolly KA, Cui C, Fagerberg E, Mariuzza DL, Hornick NI, Foster GG, William I, Cheung JF, Joshi NS. A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma. Cell Reports Methods 2021, 1: 100080. PMID: 34632444, PMCID: PMC8500377, DOI: 10.1016/j.crmeth.2021.100080.Peer-Reviewed Original ResearchConceptsLung adenocarcinomaNeoantigen expressionTumor-specific CD8 T cellsCD8 T cellsImmune checkpoint therapyInfection-induced inflammationExpression of neoantigensCommon lung cancerLUAD cell linesCheckpoint therapyLung cancerTherapeutic responseT cellsImmune responseMouse modelCell responsesTumor inductionTumorsAdenocarcinomaCell linesNeoantigensKrasFuture studiesExpressionImmunotherapy
2013
Radio‐responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors
Gerber S, Lim J, Connolly K, Sedlacek A, Barlow M, Murphy S, Egilmez N, Lord E. Radio‐responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors. International Journal Of Cancer 2013, 134: 2383-2392. PMID: 24154990, PMCID: PMC3949198, DOI: 10.1002/ijc.28558.Peer-Reviewed Original ResearchConceptsRadiation therapyIL-12Immune cellsImmune responseEffectiveness of RTEfficacy of RTCD8 T cellsIntratumoral immune cellsCytokines IL-12Effectiveness of therapyOutcome of radiotherapyEfficacy of treatmentComplete remissionResponsive tumorsCure rateNonresponsive tumorsT cellsImmune activityAntitumor effectsImmune systemCombinatorial treatmentTumor modelColon adenocarcinomaNonrespondersTumors