2024
Advancements in facial implantology: a review of hydroxyapatite applications and outcomes
Kauke-Navarro M, Knoedler L, Knoedler S, Safi A. Advancements in facial implantology: a review of hydroxyapatite applications and outcomes. Frontiers In Surgery 2024, 11: 1409733. PMID: 39092153, PMCID: PMC11291363, DOI: 10.3389/fsurg.2024.1409733.Peer-Reviewed Original ResearchFacial skeletal reconstructionLong-term safetySkeletal reconstructionFacial balanceTumor resectionCraniofacial surgeryAesthetic resultsFacial implantsReconstructive surgeryWeb of Science databasesInclusion criteriaPatient outcomesPatient satisfactionPatientsImplant integrationSystematic reviewSurgeryFacial reconstructionHAP implantsOutcomesGoogle ScholarScience databasesEfficacyHydroxyapatite applicationImplantationFrom standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases
Knoedler L, Huelsboemer L, Hollmann K, Alfertshofer M, Herfeld K, Hosseini H, Boroumand S, Stoegner V, Safi A, Perl M, Knoedler S, Pomahac B, Kauke-Navarro M. From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases. Frontiers In Immunology 2024, 15: 1276306. PMID: 38715609, PMCID: PMC11074450, DOI: 10.3389/fimmu.2024.1276306.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsHead and neck cancerBreast cancerMonoclonal antibodiesCheckpoint inhibitorsSkin cancerReconstructive surgeryNon-surgical treatment strategiesProlonged progression-free survivalSuboptimal treatment plansProgression-free survivalNon-surgical therapySurgical tumor resectionImpaired patient outcomeStandardized treatment algorithmSurgical therapy planningAnti-cancer strategyUnresectable tumorsConventional chemotherapyRemission rateTumor resectionCurative therapyTargeted therapyNeck cancerOncology casesSurface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation—fiction or reality?
Kauke-Navarro M, Knoedler L, Knoedler S, Deniz C, Safi A. Surface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation—fiction or reality? Frontiers In Surgery 2024, 11: 1351749. PMID: 38481611, PMCID: PMC10936457, DOI: 10.3389/fsurg.2024.1351749.Peer-Reviewed Original ResearchCraniofacial surgeryReduce complicationsCraniofacial reconstructionPatient-specific PEEK implantsPolyetheretherketone implantPolyetheretherketone patient-specific implantSystematic reviewPEEK implantsPatient-specific implantsFacial augmentationImplant failureClinical evaluationReconstructive surgerySurgeryComplicationsHuman studiesImaging modalitiesAesthetic surgeryClinical applicationLong-term studiesImplantationImplant materialsImplantologyPromote osseointegrationImprove osseointegration
2023
Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review
Knoedler L, Knoedler S, Allam O, Remy K, Miragall M, Safi A, Alfertshofer M, Pomahac B, Kauke-Navarro M. Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review. Frontiers In Surgery 2023, 10: 1266399. PMID: 38026484, PMCID: PMC10646214, DOI: 10.3389/fsurg.2023.1266399.Peer-Reviewed Original ResearchComposite allotransplantationLong-term outcomesFacial trauma patientsSevere facial disfigurementRejection episodesSurgical treatmentTrauma patientsMalignancy screeningReconstructive surgeryClinical challengeFacial traumaPaucity of studiesReconstructive strategiesNarrative reviewPatientsFacial disfigurementAllotransplantationFuture studiesSurgeryDiagnosisTraumaDisfigurementCellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell types