2008
Cognitive Effects of Risperidone in Children with Autism and Irritable Behavior
Aman MG, Hollway JA, McDougle CJ, Scahill L, Tierney E, McCracken JT, Arnold LE, Vitiello B, Ritz L, Gavaletz A, Cronin P, Swiezy N, Wheeler C, Koenig K, Ghuman JK, Posey DJ. Cognitive Effects of Risperidone in Children with Autism and Irritable Behavior. Journal Of Child And Adolescent Psychopharmacology 2008, 18: 227-236. PMID: 18582177, PMCID: PMC2935828, DOI: 10.1089/cap.2007.0133.Peer-Reviewed Original ResearchConceptsSevere behavioral disturbancesVerbal learning taskSpatial memory taskIrritable behaviorPurdue pegboard taskDouble-blind placebo-controlled parallel group designBehavioral disturbancesPlacebo-controlled parallel-group designMemory taskCognitive processesVerbal learningCognitive tasksMental ageSustained attentionHand-eye coordinationCognitive effectsCognitive performanceCancellation taskLearning taskSpatial memoryCognitive partDependent measuresPegboard taskAutismClassroom tasks
2003
Parent-Defined Target Symptoms Respond to Risperidone in RUPP Autism Study: Customer Approach to Clinical Trials
ARNOLD L, VITIELLO B, MCDOUGLE C, SCAHILL L, SHAH B, GONZALEZ N, CHUANG S, DAVIES M, HOLLWAY J, AMAN M, CRONIN P, KOENIG K, KOHN A, MCMAHON D, TIERNEY E. Parent-Defined Target Symptoms Respond to Risperidone in RUPP Autism Study: Customer Approach to Clinical Trials. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 1443-1450. PMID: 14627879, DOI: 10.1097/00004583-200312000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAffectAggressionAutistic DisorderChildClinical Trials as TopicDopamine AntagonistsDouble-Blind MethodEndpoint DeterminationFemaleHumansMaleObserver VariationParent-Child RelationsPlacebosResearch DesignRisperidoneSeverity of Illness IndexStereotyped BehaviorTreatment OutcomeConceptsAberrant Behavior Checklist-Irritability subscaleClinical trialsIrritability subscaleClinical Global Impression-ImprovementDouble-blind trialPediatric Psychopharmacology Autism NetworkChief complaintCommon symptomsTarget symptomsEfficacy assessmentIrritable behaviorSymptom categoriesRisperidoneChange scoresSymptomsEffect size dInterrater reliabilityTrialsPlaceboTreatment effectsClinical applicationPrimary measureConsumer-friendly wayWeeksAutism Network