Intracellular signaling mechanisms associated with CD47 modified surfaces
Finley M, Clark K, Alferiev I, Levy R, Stachelek S. Intracellular signaling mechanisms associated with CD47 modified surfaces. Biomaterials 2013, 34: 8640-8649. PMID: 23948164, PMCID: PMC3804223, DOI: 10.1016/j.biomaterials.2013.07.088.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBloodCD47 AntigenChemokinesCytokinesDown-RegulationFemaleHumansJanus Kinase 2MaleMatrix Metalloproteinase 1Matrix Metalloproteinase 13Matrix Metalloproteinase 7Middle AgedPolyvinyl ChlorideSignal TransductionSTAT Transcription FactorsTranscription, GeneticTranscriptional ActivationUp-RegulationYoung AdultConceptsTranscription factor bindingDifferential molecular responsesJAK/STATChromatin associationCell signaling levelsSynthetic polymeric surfacesTranscriptional changesFactor bindingDownregulation of cytokinesJAK-STATRelated genesUpregulation of MMPsInflammatory cell responseExposure of bloodInflammatory cell interactionsMolecular responseTranscriptionQPCR arrayCell interactionsInflammatory responseHuman whole bloodCell responsesCD47BloodWhole blood