An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1
Aftab F, Rodriguez-Fuguet A, Silva L, Kobayashi I, Sun J, Politi K, Levantini E, Zhang W, Kobayashi S, Zhang W. An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1. British Journal Of Cancer 2023, 128: 1647-1664. PMID: 36810913, PMCID: PMC10133251, DOI: 10.1038/s41416-023-02196-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorErbB ReceptorsLungLung NeoplasmsMiceMice, TransgenicMucin-1Oncogene ProteinsPurinesConceptsProtein-protein interactionsProximity ligation assayWhole transcriptomic profileEGFR inhibitorsMUC1-CTThermal stability assaysRNA sequencingTransgenic micePurine biosynthesisTranscriptomic profilesAICARTumor cell growthLigation assayMucin 1DNA damageCell growthMethodsCell viabilityLung tumor tissuesTumor formationCancer cellsEGFR-mutant lung cancerStability assaysJAKJAK1Dual immunofluorescence staining