2023
The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study
Shic F, Barney E, Naples A, Dommer K, Chang S, Li B, McAllister T, Atyabi A, Wang Q, Bernier R, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Johnson S, Sabatos‐DeVito M, Helleman G, Senturk D, Sugar C, Webb S, McPartland J, Chawarska K, Trials T. The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study. Autism Research 2023, 16: 2150-2159. PMID: 37749934, PMCID: PMC11003770, DOI: 10.1002/aur.3026.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial attention taskSchool-aged childrenAttention taskASD groupSpectrum disorderEye-tracking taskTotal T-scoreAttentional patternsAutism spectrumTD groupPresentation timeTrial feasibility studyGroup differencesPercent of timeOlder childrenTaskComparison groupToddlersT-scoreChildrenChildren 4Outcome variablesFaceCondition effectsModeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Jourdon A, Wu F, Mariani J, Capauto D, Norton S, Tomasini L, Amiri A, Suvakov M, Schreiner J, Jang Y, Panda A, Nguyen C, Cummings E, Han G, Powell K, Szekely A, McPartland J, Pelphrey K, Chawarska K, Ventola P, Abyzov A, Vaccarino F. Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis. Nature Neuroscience 2023, 26: 1505-1515. PMID: 37563294, PMCID: PMC10573709, DOI: 10.1038/s41593-023-01399-0.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderAutistic DisorderHumansMaleNeurogenesisNeuronsOrganoidsProsencephalonConceptsIdiopathic autism spectrum disorderCortical neuron subtypesAutism spectrum disorderEarly cortical developmentCortical organoidsCortical plateExcitatory neuronsCortical developmentRare formNeuron subtypesUnaffected fatherASD pathogenesisForebrain organoidsEarly neurogenesisRare variantsIdiopathic autismRisk genesTranscriptomic alterationsNeuronsProbandsSingle-cell transcriptomicsForebrain developmentSpectrum disorderTranscriptomic changesAlterationsEvaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials
Faja S, Sabatos‐DeVito M, Sridhar A, Kuhn J, Nikolaeva J, Sugar C, Webb S, Bernier R, Sikich L, Hellemann G, Senturk D, Naples A, Shic F, Levin A, Seow H, Dziura J, Jeste S, Chawarska K, Nelson C, Dawson G, McPartland J, Trials A. Evaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials. Autism Research 2023, 16: 981-996. PMID: 36929131, PMCID: PMC10192100, DOI: 10.1002/aur.2905.Peer-Reviewed Original Research
2022
Concomitant medication use in children with autism spectrum disorder: Data from the Autism Biomarkers Consortium for Clinical Trials
Shurtz L, Schwartz C, DiStefano C, McPartland JC, Levin AR, Dawson G, Kleinhans NM, Faja S, Webb SJ, Shic F, Naples AJ, Seow H, Bernier RA, Chawarska K, Sugar CA, Dziura J, Senturk D, Santhosh M, Jeste SS. Concomitant medication use in children with autism spectrum disorder: Data from the Autism Biomarkers Consortium for Clinical Trials. Autism 2022, 27: 952-966. PMID: 36086805, PMCID: PMC9995606, DOI: 10.1177/13623613221121425.Peer-Reviewed Original ResearchMeSH KeywordsAntipsychotic AgentsAutism Spectrum DisorderAutistic DisorderChildHumansPsychotropic DrugsConceptsConcomitant psychotropic medicationsPsychotropic medicationsClinical trialsMedication useSchool-aged childrenClinical representativenessSelective serotonin reuptake inhibitorsConcomitant medication useVariety of medicationsAutism spectrum disorderSerotonin reuptake inhibitorsPsychotropic medication useNew treatment optionsGreater overall impairmentCentral nervous systemSpectrum disorderMedication classesReuptake inhibitorsAlpha agonistsTreatment optionsClinical endpointsInclusion criteriaStudy populationMedicationsNervous systemThe Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers
Webb SJ, Naples AJ, Levin AR, Hellemann G, Borland H, Benton J, Carlos C, McAllister T, Santhosh M, Seow H, Atyabi A, Bernier R, Chawarska K, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Nelson CA, Sabatos-DeVito M, Senturk D, Shic F, Sugar CA, McPartland JC. The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers. American Journal Of Psychiatry 2022, 180: 41-49. PMID: 36000217, PMCID: PMC10027395, DOI: 10.1176/appi.ajp.21050485.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderAutistic DisorderBiomarkersClinical Trials as TopicElectroencephalographyEvoked Potentials, VisualHumansConceptsBiological motion perceptionAutism spectrum disorderResting-state activityMotion perceptionEEG biomarkersGroup discriminationPsychometric propertiesBasic psychometric propertiesASD groupASD diagnosisNeural responsesSpectrum disorderAlpha powerN170Naturalistic studyPerceptionMixed resultsTask latencyVEP amplitudeContext of useLimited attentionInconsistent resultsAcquisition rateDiscriminationBatteriesFunctional Connectome–Based Predictive Modeling in Autism
Horien C, Floris DL, Greene AS, Noble S, Rolison M, Tejavibulya L, O'Connor D, McPartland JC, Scheinost D, Chawarska K, Lake EMR, Constable RT. Functional Connectome–Based Predictive Modeling in Autism. Biological Psychiatry 2022, 92: 626-642. PMID: 35690495, PMCID: PMC10948028, DOI: 10.1016/j.biopsych.2022.04.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAutism Spectrum DisorderAutistic DisorderBrainConnectomeForecastingHumansMagnetic Resonance ImagingAttention to audiovisual speech does not facilitate language acquisition in infants with familial history of autism
Chawarska K, Lewkowicz D, Feiner H, Macari S, Vernetti A. Attention to audiovisual speech does not facilitate language acquisition in infants with familial history of autism. Journal Of Child Psychology And Psychiatry 2022, 63: 1466-1476. PMID: 35244219, DOI: 10.1111/jcpp.13595.Peer-Reviewed Original ResearchConceptsExpressive language scoresLanguage outcomesAudiovisual cuesSpeaker's faceLanguage scoresLanguage acquisitionLanguage delayBetter language outcomesSiblings of childrenFamilial riskLow familial riskPoor language outcomesLow-risk infantsAudiovisual speechIntact attentionSpeech cuesHigh familial riskPromising endophenotypeASD diagnosisSpeech processingCuesHigh-risk infantsAutismASDFace
2021
What are we optimizing for in autism screening? Examination of algorithmic changes in the M‐CHAT
Schjølberg S, Shic F, Volkmar FR, Nordahl‐Hansen A, Stenberg N, Torske T, Larsen K, Riley K, Sukhodolsky DG, Leckman JF, Chawarska K, Øien RA. What are we optimizing for in autism screening? Examination of algorithmic changes in the M‐CHAT. Autism Research 2021, 15: 296-304. PMID: 34837355, PMCID: PMC8821132, DOI: 10.1002/aur.2643.Peer-Reviewed Original ResearchPuppets facilitate attention to social cues in children with ASD
Macari S, Chen X, Brunissen L, Yhang E, Brennan‐Wydra E, Vernetti A, Volkmar F, Chang J, Chawarska K. Puppets facilitate attention to social cues in children with ASD. Autism Research 2021, 14: 1975-1985. PMID: 34350712, PMCID: PMC8434944, DOI: 10.1002/aur.2552.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderVisual attentionAutism severityTD controlsSpeaker's faceYoung childrenSocial-communicative cuesSpeakers’ preferencesHigher autism severityAttention of childrenFunction of groupASD groupSocial cuesSpectrum disorderVisual preferenceHuman speakersSocial partnersSocial interactionSpeaker identityPuppetCuesChildrenEarly characteristicsReciprocal interactionsFace
2020
Attend Less, Fear More: Elevated Distress to Social Threat in Toddlers With Autism Spectrum Disorder
Macari SL, Vernetti A, Chawarska K. Attend Less, Fear More: Elevated Distress to Social Threat in Toddlers With Autism Spectrum Disorder. Autism Research 2020, 14: 1025-1036. PMID: 33283976, PMCID: PMC7772932, DOI: 10.1002/aur.2448.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderAutistic DisorderChild, PreschoolCognitionEmotionsFearHumansInfantConceptsAutism symptom severitySocial threatEmotional reactivityNegative emotional responsesER strategiesAmbiguous threatThreat valueEmotional responsesSocial situationsAutism Diagnostic Observation Schedule-2Potential social threatEmotion regulation strategiesER strategy useDifferential emotional reactivitySymptom severityMechanisms of changeIntensity of distressNonsocial stimuliNonsocial threatAttentional salienceTD toddlersEmotional salienceAutism phenotypeAutism severityRegulation strategiesSex Differences in Gender‐Diverse Expressions and Identities among Youth with Autism Spectrum Disorder
Brunissen L, Rapoport E, Chawarska K, Adesman A. Sex Differences in Gender‐Diverse Expressions and Identities among Youth with Autism Spectrum Disorder. Autism Research 2020, 14: 143-155. PMID: 33283980, DOI: 10.1002/aur.2441.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxietyAutism Spectrum DisorderAutistic DisorderChildFemaleGender IdentityHumansMaleSex CharacteristicsConceptsAutism spectrum disorderGender-related concernsGender Identity QuestionnaireParents of girlsSpectrum disorderASD ages 6Sex differencesParents of youthParents of boysIndividualized supportGender identity/expressionSex-typed behaviorSame-gender behaviorElevated distressIdentity QuestionnaireParents' responsesAutismChild's appearanceChild's ageAge 6Gender expressionReal distressBirth sexYouthGender dysphoria
2013
Gaze Response to Dyadic Bids at 2 Years Related to Outcomes at 3 Years in Autism Spectrum Disorders: A Subtyping Analysis
Campbell DJ, Shic F, Macari S, Chawarska K. Gaze Response to Dyadic Bids at 2 Years Related to Outcomes at 3 Years in Autism Spectrum Disorders: A Subtyping Analysis. Journal Of Autism And Developmental Disorders 2013, 44: 431-442. PMID: 23877749, PMCID: PMC3900601, DOI: 10.1007/s10803-013-1885-9.Peer-Reviewed Original ResearchMeSH KeywordsAttentionAutistic DisorderChild Development Disorders, PervasiveChild, PreschoolCuesEye MovementsFaceFemaleHumansInfantMaleConceptsAutism spectrum disorderSpectrum disorderChild-directed speechVisual responsesDirect gazeAdaptive functioningSocial scenesSpeaker's mouthHigh functioningBetter attentionCuesToddlersFunctioningLimited attentionEarly predictorAttentionDisordersSpeechSceneGazeYears of ageLanguageEngagementOutcomesMeaningful approach
2012
Context modulates attention to social scenes in toddlers with autism
Chawarska K, Macari S, Shic F. Context modulates attention to social scenes in toddlers with autism. Journal Of Child Psychology And Psychiatry 2012, 53: 903-913. PMID: 22428993, PMCID: PMC3845814, DOI: 10.1111/j.1469-7610.2012.02538.x.Peer-Reviewed Original ResearchConceptsSocial attentionSpeaker's faceTypical developmentSocial scenesAtypical language profileDistribution of attentionPresence of salientNonsocial cuesAttentional responsesSocial cognitionTD controlsLanguage profilesNonverbal functioningEye contactLip movementsAutismEntire sceneSocial monitoringCuesToddlersVisual fieldSymptom severityPresent momentVisual responsesDevelopmental delay
2011
Early Generalized Overgrowth in Boys With Autism
Chawarska K, Campbell D, Chen L, Shic F, Klin A, Chang J. Early Generalized Overgrowth in Boys With Autism. JAMA Psychiatry 2011, 68: 1021-1031. PMID: 21969460, PMCID: PMC4878118, DOI: 10.1001/archgenpsychiatry.2011.106.Peer-Reviewed Original ResearchMeSH KeywordsAutistic DisorderBayes TheoremBody HeightBody WeightCase-Control StudiesHeadHumansInfantMaleMegalencephalyRetrospective StudiesConceptsLower adaptive functioningAdaptive functioning levelPervasive developmental disorderCognitive functioningAdaptive functioningCognitive featuresSocial deficitsHC growthAge-related changesUniversity-based clinicAutismFunctioning levelsAge 24 monthsAutistic disorderClinical groupsDevelopmental disordersDevelopmental problemsFunctioningDevelopmental delayBoysAge 2 yearsGeneralized overgrowthOvergrowth patternGreater severityFirst year
2010
Limited Attentional Bias for Faces in Toddlers With Autism Spectrum Disorders
Chawarska K, Volkmar F, Klin A. Limited Attentional Bias for Faces in Toddlers With Autism Spectrum Disorders. JAMA Psychiatry 2010, 67: 178-185. PMID: 20124117, PMCID: PMC4871149, DOI: 10.1001/archgenpsychiatry.2009.194.Peer-Reviewed Original ResearchConceptsAttention disengagementVisual attentionRelevant stimuliDeep processingFace-processing difficultiesPoor face recognitionFace processing deficitsDisengagement of attentionCentral fixation stimulusAutism spectrum disorderSaccadic reaction timesBetween-groups factorAttentional biasSocial cognitionAttention taskAttentional mechanismsNonfacial stimuliAttentional levelStimulus typeSpectrum disorderTypical individualsReactive saccadesFixation stimulusASDGeneralized impairment
2009
Clinical Assessment and Management of Toddlers With Suspected Autism Spectrum Disorder: Insights From Studies of High-Risk Infants
Zwaigenbaum L, Bryson S, Lord C, Rogers S, Carter A, Carver L, Chawarska K, Constantino J, Dawson G, Dobkins K, Fein D, Iverson J, Klin A, Landa R, Messinger D, Ozonoff S, Sigman M, Stone W, Tager-Flusberg H, Yirmiya N. Clinical Assessment and Management of Toddlers With Suspected Autism Spectrum Disorder: Insights From Studies of High-Risk Infants. Pediatrics 2009, 123: 1383-1391. PMID: 19403506, PMCID: PMC2833286, DOI: 10.1542/peds.2008-1606.Peer-Reviewed Original ResearchMeSH KeywordsAutistic DisorderChild DevelopmentCommunicationHealth Status IndicatorsHumansInfantInfant BehaviorLanguageSurveys and QuestionnairesConceptsAge groupsEarly signsDiagnostic assessmentAutism spectrum disorderHigh-risk infantsCurrent diagnostic guidelinesSpectrum disorderYears of ageRecent American AcademyImportant age groupPediatrics recommendationsClinical assessmentDiagnostic guidelinesEarly detection toolAmerican AcademyEffective interventionsEarly detectionDisordersYoung childrenIntervention approachesChildrenAgeOngoing studiesCurrent knowledgeCurrent best practice
2008
Language outcomes of toddlers with autism spectrum disorders: a two year follow‐up
Paul R, Chawarska K, Cicchetti D, Volkmar F. Language outcomes of toddlers with autism spectrum disorders: a two year follow‐up. Autism Research 2008, 1: 97-107. PMID: 19360656, PMCID: PMC2946084, DOI: 10.1002/aur.12.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNonverbal IQLanguage outcomesSpectrum disorderEL outcomesDiagnosis of ASDJoint attention bidsExpressive language outcomesReceptive language scoresExpressive communication skillsNonverbal scoresLanguage scoresAutistic symptomsCognitive levelRepetitive behaviorsAge fourCommunication scoresNumber of soundsCommunication skillsSignificant predictionPlay schemesIQSecond yearStandard measuresOutcome groupMolecular Cytogenetic Analysis and Resequencing of Contactin Associated Protein-Like 2 in Autism Spectrum Disorders
Bakkaloglu B, O'Roak BJ, Louvi A, Gupta AR, Abelson JF, Morgan TM, Chawarska K, Klin A, Ercan-Sencicek AG, Stillman AA, Tanriover G, Abrahams BS, Duvall JA, Robbins EM, Geschwind DH, Biederer T, Gunel M, Lifton RP, State MW. Molecular Cytogenetic Analysis and Resequencing of Contactin Associated Protein-Like 2 in Autism Spectrum Disorders. American Journal Of Human Genetics 2008, 82: 165-173. PMID: 18179895, PMCID: PMC2253974, DOI: 10.1016/j.ajhg.2007.09.017.Peer-Reviewed Original ResearchConceptsAutism susceptibility candidate 2Contactin 4Plasma membrane fractionSynaptic plasma membrane fractionMolecular cytogenetic analysisComplex genetic etiologyRare variantsBioinformatics approachConserved positionNonsynonymous changesMembrane fractionRare homozygous mutationControl chromosomesBiochemical analysisNeurodevelopmental syndromeGenetic etiologyPathophysiology of ASDCandidate 2Recent findingsHomozygous mutationUnrelated familiesCytogenetic analysisMutationsVariantsResequencing
2007
“Listen My Children and You Shall Hear”: Auditory Preferences in Toddlers With Autism Spectrum Disorders
Paul R, Chawarska K, Fowler C, Cicchetti D, Volkmar F. “Listen My Children and You Shall Hear”: Auditory Preferences in Toddlers With Autism Spectrum Disorders. Journal Of Speech Language And Hearing Research 2007, 50: 1350-1364. PMID: 17905916, DOI: 10.1044/1092-4388(2007/094).Peer-Reviewed Original ResearchConceptsAutism spectrum disorderChild-directed speechAuditory preferenceSpectrum disorderReceptive language abilityLater language developmentASD performASD showReceptive languageLanguage ageLanguage abilityTypical peersAuditory stimuliLanguage developmentCorrelational analysisDevelopmental disabilitiesPreference paradigmDevelopmental disordersLanguage patternsContrast groupYoung childrenToddlersSpeechChildrenDisordersThe Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders
Kleinman JM, Robins DL, Ventola PE, Pandey J, Boorstein HC, Esser EL, Wilson LB, Rosenthal MA, Sutera S, Verbalis AD, Barton M, Hodgson S, Green J, Dumont-Mathieu T, Volkmar F, Chawarska K, Klin A, Fein D. The Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders. Journal Of Autism And Developmental Disorders 2007, 38: 827-839. PMID: 17882539, PMCID: PMC3612529, DOI: 10.1007/s10803-007-0450-9.Peer-Reviewed Original ResearchMeSH KeywordsAutistic DisorderChild, PreschoolEarly DiagnosisFemaleFollow-Up StudiesHumansMaleMass ScreeningSurveys and QuestionnairesConceptsAutism spectrum disorderPositive predictive valueModified ChecklistSpectrum disorderTelephone interviewsEarly detectionHigh-risk sampleLow-risk sampleHigh-risk sourceM-CHATPositive casesPredictive valueReferral sourceToddlersPromising instrumentAutismInitial screeningChildrenMonthsDisordersChecklistScreeningInterviewsFollow