2024
Familial Recurrence of Autism: Updates From the Baby Siblings Research Consortium.
Ozonoff S, Young G, Bradshaw J, Charman T, Chawarska K, Iverson J, Klaiman C, Landa R, McDonald N, Messinger D, Schmidt R, Wilkinson C, Zwaigenbaum L. Familial Recurrence of Autism: Updates From the Baby Siblings Research Consortium. Pediatrics 2024, 154 PMID: 39011552, PMCID: PMC11291960, DOI: 10.1542/peds.2023-065297.Peer-Reviewed Original ResearchRecurrence rateFamilial recurrence rateDatabase of infantsMale infant sexPredictors of recurrenceAssociated with recurrencePopulation-based studyMultiple affected siblingsProspective studyInfant sexHierarchical generalized linear modelsDiagnostic evaluationFamilial recurrenceAutism spectrum disorderRecurrenceResearch ConsortiumFemale probandsMultinational databaseMale probandsMaternal educationProbandsFemale siblingsProband sexLikelihood ratioCalculate likelihood ratios
2023
Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Jourdon A, Wu F, Mariani J, Capauto D, Norton S, Tomasini L, Amiri A, Suvakov M, Schreiner J, Jang Y, Panda A, Nguyen C, Cummings E, Han G, Powell K, Szekely A, McPartland J, Pelphrey K, Chawarska K, Ventola P, Abyzov A, Vaccarino F. Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis. Nature Neuroscience 2023, 26: 1505-1515. PMID: 37563294, PMCID: PMC10573709, DOI: 10.1038/s41593-023-01399-0.Peer-Reviewed Original ResearchConceptsIdiopathic autism spectrum disorderCortical neuron subtypesAutism spectrum disorderEarly cortical developmentCortical organoidsCortical plateExcitatory neuronsCortical developmentRare formNeuron subtypesUnaffected fatherASD pathogenesisForebrain organoidsEarly neurogenesisRare variantsIdiopathic autismRisk genesTranscriptomic alterationsNeuronsProbandsSingle-cell transcriptomicsForebrain developmentSpectrum disorderTranscriptomic changesAlterations