2000
Evidence for a Functional Association between Phosphatidylinositol 3-Kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1*
Grey A, Chen Y, Paliwal I, Carlberg K, Insogna K. Evidence for a Functional Association between Phosphatidylinositol 3-Kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1*. Endocrinology 2000, 141: 2129-2138. DOI: 10.1210/en.141.6.2129.Peer-Reviewed Original ResearchC-SrcPhosphatidylinositol 3-kinasePI3K activityColony-stimulating factor-1SH3 domainPI3KSH3 domain of c-SrcRegulatory subunit of PI3KActivation of phosphatidylinositol 3-kinaseSubunit of PI3KProline-rich sequenceActivation of PI3KIntracellular signaling moleculesRegulatory subunitOsteoclast cytoskeletonCytoskeletal changesColony-stimulating factor 1 treatmentOsteoclast motilitySignaling moleculesFunctional associationGrowth factor/cytokineSignaling pathwayInhibitor wortmanninTreatment of osteoclast-like cellsReceptor c-fms
1993
Macrophage colony‐stimulating factor release and receptor expression in bone cells
Weir E, Horowitz M, Baron R, Centrella M, Kacinski B, Insogna K. Macrophage colony‐stimulating factor release and receptor expression in bone cells. Journal Of Bone And Mineral Research 1993, 8: 1507-1518. PMID: 8304053, DOI: 10.1002/jbmr.5650081214.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowBone Marrow CellsCell DivisionCells, CulturedColony-Forming Units AssayCulture Media, ConditionedGranulocyte-Macrophage Colony-Stimulating FactorMacrophage Colony-Stimulating FactorMacrophagesMaleOsteoblastsOsteoclastsParathyroid HormoneParathyroid Hormone-Related ProteinProteinsRatsRats, Sprague-DawleyRats, WistarReceptor, Macrophage Colony-Stimulating FactorTumor Cells, CulturedConceptsColony-stimulating factorColony-stimulating activityM-CSFBone resorptionReceptor expressionMature osteoclastsPreincubation of CMColony-stimulating factor releaseHormone-related peptideM-CSF receptor c-FmsMacrophage colony-stimulating factorOsteoblast-osteoclast interactionsM-CSF mRNA levelsBone marrow cellsCSF-1 receptor expressionRat bone marrow cellsReceptor c-fmsROS 17/2.8 cellsParacrine roleImmunohistochemical techniquesRat osteoblastsPTHrP treatmentMarrow cellsFactor releasePTH