1988
Humoral Hypercalcemia of Malignancy in Canine Lymphosarcoma*
Weir EC, Norrdin RW, Matus RE, Brooks MB, Broadus AE, Mitnick M, Johnston SD, Insogna KL. Humoral Hypercalcemia of Malignancy in Canine Lymphosarcoma*. Endocrinology 1988, 122: 602-608. PMID: 2828006, DOI: 10.1210/endo-122-2-602.Peer-Reviewed Original ResearchConceptsAdenylate cyclase-stimulating activityHypercalcemic dogsCanine lymphosarcomaFractional phosphorus excretionEvidence of tumorQuantitative bone histomorphometryBone-resorbing factorsImmunoreactive PTH levelsPathogenesis of hypercalcemiaIliac crest biopsiesTumor tissue extractsCyclase-stimulating activityBone histomorphometric findingsCalcium excretionPTH levelsHumoral hypercalcemiaDihydroxyvitamin DBone resorptionHistomorphometric findingsBone histomorphometryPTH receptorBiopsy siteCrest biopsiesTumor extractsCompensatory increase
1984
Biochemical and Histomorphometric Characterization of a Rat Model for Humoral Hypercalcemia of Malignancy*
INSOGNA K, STEWART A, VIGNERY A, WEIR E, NAMNUM P, BARON R, KIRKWOOD J, DEFTOS L, BROADUS A. Biochemical and Histomorphometric Characterization of a Rat Model for Humoral Hypercalcemia of Malignancy*. Endocrinology 1984, 114: 888-896. PMID: 6546543, DOI: 10.1210/endo-114-3-888.Peer-Reviewed Original ResearchConceptsTumor-bearing animalsBone-resorbing activityHumoral hypercalcemiaDay 13Dihydroxyvitamin D valuesFractional phosphorus excretionQuantitative bone histomorphometryAction of PTHImmunoreactive PTH levelsTumor-bearing groupLeydig cell tumorMale Fisher ratsBone cell functionPTH levelsNephrogenous cAMPDihydroxyvitamin DTumor transplantationCell tumorsBone resorptionBone histomorphometryRat modelTumor groupControl animalsFisher ratsMarked suppression