THE PARATHYROID HORMONE-RELATED PROTEIN STIMULATES HUMAN OSTEOBLAST-LIKE CELLS TO SECRETE A 9,000 DALTON BONERESORBING PROTEIN
Morris CA, Mitnick ME, Weir EC, Horowitz M, Kreider BL, Insogna KL. THE PARATHYROID HORMONE-RELATED PROTEIN STIMULATES HUMAN OSTEOBLAST-LIKE CELLS TO SECRETE A 9,000 DALTON BONERESORBING PROTEIN. Endocrinology 1990, 126: 1783-1786. PMID: 2307127, DOI: 10.1210/endo-126-3-1783.Peer-Reviewed Original ResearchConceptsParathyroid hormone-related proteinBone-resorbing activityHormone-related proteinBone resorptionPTH/Bone-resorbing cytokinesIL-1GM-CSFSingle fractionSequential reverse-phase HPLCII cellsUntreated cellsKD fractionHuman osteoblast-like cellsResorptionSize-exclusion HPLCNgeqOsteoblast-like cellsSpecific activityCellsKD proteinOsteoblastsReversed-phase HPLCCytokinesPGE2