2014
Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats
Cao C, Thomas CE, Insogna KL, O'Brien KO. Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats. Journal Of Nutrition 2014, 144: 1710-1717. PMID: 25332470, PMCID: PMC4195416, DOI: 10.3945/jn.114.197939.Peer-Reviewed Original ResearchConceptsNonheme iron absorptionDivalent metal transporter 1Tissue utilizationLiver hepcidinDietary hemeMale Sprague-Dawley ratsDuodenal iron transportersHeme iron absorptionSprague-Dawley ratsHepatic hepcidin expressionIron storage tissuesIron loadingElevated hepcidinIron intakeMetal transporter 1Duodenal absorptionIron dextranNonheme ironIron overloadRat modelHepcidin expressionHepatic hepcidinStable iron isotopesDuodenal expressionHepcidin
2013
Differential effects of hepcidin on heme and nonheme iron absorption in a rat model of iron overload
Cao C, Thomas C, Insogna K, O'Brien K. Differential effects of hepcidin on heme and nonheme iron absorption in a rat model of iron overload. The FASEB Journal 2013, 27: 634.18-634.18. DOI: 10.1096/fasebj.27.1_supplement.634.18.Peer-Reviewed Original ResearchFe overloadMale Sprague-Dawley ratsWeeks of treatmentFe absorptionBi-weekly injectionsNonheme iron absorptionRed cell incorporationSprague-Dawley ratsLiver hepcidinDawley ratsRat modelRats inhibitsIron overloadRodent modelsIron absorptionAlternate daysRegulatory hormonesHepcidin transcriptsHepcidinFpn degradationRatsCell incorporationGreater associationDifferential effectsPorcine RBCs